Evidence map›Paper›PMID 40604112›Full record

ArticleScientific reports2025

Alprazolam induces anterograde amnesia for contextual fear memory and alters dorsoventral hippocampal neuronal ensembles in female mice.

Kameron Kaplan, Lainey B Toennies, Holly C Hunsberger

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kameron KaplanNeuroscience Department, Rosalind Franklin University of Medicine and Science (RFUMS), 3333 Green Bay Road, North Chicago, IL, 60064, USA.
Lainey B ToenniesNeuroscience Department, Rosalind Franklin University of Medicine and Science (RFUMS), 3333 Green Bay Road, North Chicago, IL, 60064, USA.
Holly C HunsbergerNeuroscience Department, Rosalind Franklin University of Medicine and Science (RFUMS), 3333 Green Bay Road, North Chicago, IL, 60064, USA. holly.hunsberger@rosalindfranklin.edu.

Funding

The sex specific impact of anxiety on Alzheimer's disease progressionR00AG059953 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI HUNSBERGER, HOLLY CHRISTIAN · 2022 to 2024
$747k
NIA NIH HHS R00 AG059953
6 · The paper itself

Abstract

Benzodiazepines (BZDs) are commonly prescribed anxiolytic drugs that act on GABAa receptors, and can result in anterograde amnesia, or the inability to form new memories. While BZDs have been used for decades, the brain regions and neuronal mechanisms responsible for this detrimental side effect are largely unknown at the systems neuroscience level. To analyze the effects of BZDs on long-term memory, activity-dependent ArcCreER

Indexed as

AlprazolamAmnesia, AnterogradeAnti-Anxiety AgentsFearHippocampusMemoryNeuronsAnimalsFemaleMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosAlprazolamAnti-Anxiety AgentsProto-Oncogene Proteins c-fosBenzodiazepinesEngramHippocampusMemory

Identifiers

PMID40604112
PMCPMC12222850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.