Evidence map›Paper›PMID 40604037›Full record

ArticleScientific reports2025

Uptake system of lignin-derived aromatic acids in promising Sphingomonadaceae strains for lignin valorization through biological funneling.

Masaya Fujita, Ryo Hirano, Kota Nagayoshi, Naofumi Kamimura, Eiji Masai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Masaya Fujita *Department of Materials Science and Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan.
Ryo Hirano *Department of Materials Science and Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan.
Kota NagayoshiDepartment of Materials Science and Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan.
Naofumi KamimuraDepartment of Materials Science and Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan.
Eiji MasaiDepartment of Materials Science and Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan. emasai@vos.nagaokaut.ac.jp.

Funding

Japan Science and Technology Corporation JPMJPF2104Japan Society for the Promotion of Science 15H04473Japan Society for the Promotion of Science 22K14821
6 · The paper itself

Abstract

The production of value-added chemicals from lignin-derived aromatic compounds through bacterial catabolism has attracted attention. Sphingobium lignivorans SYK-6 can catabolize various lignin-derived aromatic compounds that can be used for this purpose. PcaK (Sl-PcaK), a member of the major facilitator superfamily (MFS) transporters in SYK-6, is known to be involved in the uptake of protocatechuic acid (PCA) and vanillic acid (VA) in the inner membrane. Here, we demonstrated that Sl-PcaK also mediates the uptake of 4-hydroxybenzoic acid (HBA), syringic acid (SA), and ferulic acid (FA). Saro_0804 (Na-pcaK), with 58% amino acid sequence identity to Sl-PcaK, is present in Novosphingobium aromaticivorans DSM 12444. Na-pcaK plays a role in the uptake of PCA, HBA, VA, and SA. The increased expression of Sl-pcaK or Na-pcaK in SYK-6 cells improved the conversion rates of VA, SA, and FA 1.12-1.33-fold compared with the control strain, suggesting that these genes could serve as tools to improve the production efficiency of target metabolites.

Indexed as

LigninSphingomonadaceaeBacterial ProteinsBiological TransportCoumaric AcidsGallic AcidHydroxybenzoatesParabensVanillic Acid4-hydroxybenzoic acidBacterial ProteinsCoumaric Acidsferulic acidGallic AcidHydroxybenzoatesLigninParabensprotocatechuic acidsyringic acidVanillic AcidABC transportersAromatic acidsBacterial catabolismLignin valorizationMFS transporters

Identifiers

PMID40604037
PMCPMC12223119

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.