Evidence map›Paper›PMID 40604024›Full record

ArticleScientific reports2025

Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8

Jiandong Yu, Jiayan Wu, Tianzhu Long, Lihong Lv, Zhiping Chen, Zeyu Lin, Hongquan Zhu, Guolin Li, Yunle Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiandong Yu *Department of General Surgery (Hepatobiliary, Pancreatic and Splenic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, 26 W Erheng Road, Yan Cun, Guangzhou, 510655, China.
Jiayan Wu *Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Tianzhu LongDepartment of Breast Surgery Guangzhou Women and Children's Medical Center, Guangzhou, China.
Lihong LvDrug clinical trial institution, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China.
Zhiping ChenDepartment of General Surgery (Hepatobiliary, Pancreatic and Splenic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, 26 W Erheng Road, Yan Cun, Guangzhou, 510655, China.
Zeyu LinDepartment of General Surgery (Hepatobiliary, Pancreatic and Splenic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, 26 W Erheng Road, Yan Cun, Guangzhou, 510655, China.
Hongquan ZhuDepartment of General Surgery, Jiangmen Central Hospital, Guangzhou, China.
Guolin LiDepartment of General Surgery (Hepatobiliary, Pancreatic and Splenic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, 26 W Erheng Road, Yan Cun, Guangzhou, 510655, China. liglin@mail.sysu.edu.cn.
Yunle WanDepartment of General Surgery (Hepatobiliary, Pancreatic and Splenic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, 26 W Erheng Road, Yan Cun, Guangzhou, 510655, China. wanyunle@mail.sysu.edu.cn.

Funding

National Natural Science Foundation of China 8180102403PhD Start-up Fund of Natural Science Foundation of Guangdong Province 2015A030310377
6 · The paper itself

Abstract

The roles of donor liver natural killer (NK) cells in allogeneic liver transplantation remains controversial. Herein, we investigated the effects of liver NK cells on liver allograft tolerance by using liver NK cells and allogeneic spleen T cell co-culture in vitro experiments and the rat orthotopic liver transplantation model. CD8

Indexed as

ApoptosisCD8-Positive T-LymphocytesGraft RejectionKiller Cells, NaturalLiverLiver TransplantationT-Lymphocytes, RegulatoryAllograftsAnimalsCoculture Techniquesfas ReceptorInterleukin-2 Receptor alpha SubunitMaleRatsRats, Inbred LewTransplantation, Homologousfas ReceptorInterleukin-2 Receptor alpha SubunitAllograft rejectionCD4+CD25+T lymphocytesImmunoregulationLiver NK cellsLiver transplantation

Identifiers

PMID40604024
PMCPMC12222650

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.