Evidence map›Paper›PMID 40603996›Full record

ArticleScientific reports2025

XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.

Xixi Wu, Li He, Yonghong Lin, Yunfeng Zheng, Peng Jiang, Chenfan Tian, Ran Mao, Bo Yang, Yuanling Shi, Huisheng Ge and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xixi WuDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li HeDepartment of Obstetrics and Gynecology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yonghong LinDepartment of Obstetrics and Gynecology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yunfeng ZhengDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Peng JiangDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chenfan TianDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ran MaoDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Bo YangDepartment of Obstetrics and Gynecology, People's Hospital of Xiushan County, Chongqing, China.
Yuanling ShiInternational Medical College, Chongqing Medical University, Chongqing, China.
Huisheng GeDepartment of Obstetrics and Gynecology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 1347362738@qq.com.
Jianguo HuDepartment of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, Linjiang Road, No. 76, Chongqing, China. angeljianguo@hospital.cqmu.edu.cn.
Rui YuanDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. yrui96@hospital.cqmu.edu.cn.

Funding

Chongqing Science and Technology Program CSTB2024TIAD-KPX0038Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University kryc-yq-2104, kryc-yq-2222Natural Science Foundation of Chongqing Municipality CSTB2022NSCQ-MSX0071
6 · The paper itself

Abstract

Intrauterine adhesion (IUA) was characterized by endometrial fibrosis, leading primarily to hypomenorrhea, infertility and recurrent miscarriage. Epithelial-mesenchymal transition (EMT) is now recognized as a key factor in the development of endometrial fibrosis. X-box binding protein 1 (XBP1), as a crucial transcription factor, has emerged as a potential target for anti-fibrosis treatment in the liver due to its role in various tissue fibrosis. However, the function and molecular mechanisms of XBP1 in the endometrium of patients with IUA are not well understood. In this study, we identified abnormal expression of XBP1, epithelial-mesenchymal transition (EMT) markers, and the cGAS-STING pathway in endometrial tissues from patients with IUA and in IUA-like mouse models. XBP1 was found to promote EMT in endometrial epithelial cells by activating the cGAS-STING pathway and cytoplasmic release of mitochondrial DNA. The addition of mitochondrial membrane inhibition VBIT-4 reversed TGF-β1-induced EMT in vitro. Inhibition of XBP1 reduced endometrial fibrosis and the cGAS-STING pathway activity in the IUA-like mouse models, while activation of XBP1 caused the opposite outcome. These findings indicate XBP1 may serve as a potential therapeutic target for IUA.

Indexed as

EndometriumMembrane ProteinsNucleotidyltransferasesSignal TransductionX-Box Binding Protein 1AdultAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease Models, AnimalEpithelial-Mesenchymal TransitionFemaleFibrosisHumansMiceSTING ProteinTransforming Growth Factor beta1cGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSting1 protein, mouseSTING ProteinTransforming Growth Factor beta1X-Box Binding Protein 1XBP1 protein, humanXbp1 protein, mousecGAS-STINGEpithelial-mesenchymal transformation (EMT)Intrauterine adhesion (IUA)Mitochondria DNA (mtDNA)XBP1

Identifiers

PMID40603996
PMCPMC12223152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.