ArticleScientific reports2025
Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- The role of cytosolic mitochondrial DNA as a mitochondrial danger signal for stromal fibroblasts in forming the tumor-promoting microenvironment following radiation exposure.Journal of radiation research · 2026Review
- MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA.Cell death and differentiation · 2026Article
- Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults.International journal of radiation biology · 2026Article
- The mitochondrial protease, LonP1, is a potential cardioprotective target for attenuating doxorubicin-induced cardiomyocyte death.Journal of translational medicine · 2026Article
- Molecular mechanisms regulating cGAS/STING activation in health and disease.The Journal of clinical investigation · 2026Review
- A Mitochondria-Targeted Nitroxide Radical Mitigates Radiation-Induced Liver Injury by Attenuating Oxidative Stress and Preserving Mitochondrial Function.Antioxidants (Basel, Switzerland) · 2026Article
- Application Mechanisms and Clinical Prospects of Brain-Computer Interface Technology in Radiation-Induced Brain Injury.Cellular and molecular neurobiology · 2026Review
- TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.Communications biology · 2026Article
- Review
- Ionizing radiation: molecular mechanisms, biological effects, and therapeutic targets.Molecular biomedicine · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Inflammatory responses are crucial for repairing radiation-induced tissue damage. Excessive tissue remodeling in response to severe tissue injury causes chronic inflammation associated with various diseases including cardiovascular disease and cancer. Fibroblasts are major components of the stroma and play key roles in tissue remodeling. However, causes of inflammatory response activation remain unclear. This study focused on cytosolic mitochondrial DNA (mtDNA) release and its role in inflammation following irradiation. Cytosolic mtDNA leakage increased 3 h after irradiation of normal human fibroblasts and persisted for at least 7 days. H
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Registered trials
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