ArticleScientific reports2025
Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease.
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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Defining the vascular niche of human adipose tissue across metabolic states.Nature metabolism · 2026Article
- A peptide-based PROTAC targeting FOXM1 suppresses fibrosis-associated hepatocarcinogenesis.Theranostics · 2026Article
- Defining the vascular niche of human adipose tissue across metabolic states.bioRxiv : the preprint server for biology · 2025Article
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20 authors.
Wouter DheedeneDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0001-8798-0395
Stefaan VerhulstLiver Cell Biology research group, Vrije Universiteit Brussel, Brussels, Belgium.
Louise DemuynckDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Bram CallewaertDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Willeke de HaanDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Stefan VinckierDepartment of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven, Leuven, Belgium.
Jore Van WauweDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Petra VandervoortDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Marleen LoxDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Mathias StroobantsDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Renaud Lavend'hommeDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Wilfred F J van IJckenCenter for Biomics-Genomics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0421-8301
Elizabeth A V JonesDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
An ZwijsenDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0002-8583-1721
Marc JacqueminDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.
Leo A van GrunsvenLiver Cell Biology research group, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-0990-7034
Kimberly MartinodDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0002-1026-6107
Danny HuylebroeckDepartment of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4862-1079
Eskeatnaf MulugetaDepartment of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Aernout LuttunDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Endothelial Cell Biology Unit, KU Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, box 911, Leuven, 3000, Belgium. aernout.luttun@kuleuven.be.ORCID http://orcid.org/0000-0001-7902-9524
Funding
Cosmetics Europe/European Commission FP7 Grant FP7-Health-HemiBio266777EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) FP7-StG-IMAGINED203291EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme "People" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) H2020-MSCA-IF-REZONABLE658666EC | EU Framework Programme for Research and Innovation H2020 | H2020 Excellent Science (H2020 Priority Excellent Science) H2020 848109-CRUCIALErasmus University Rotterdam | Erasmus Universitair Medisch Centrum Rotterdam (Erasmus Universitair Medisch Centrum) BIG project fundingErasmus University Rotterdam | Erasmus Universitair Medisch Centrum Rotterdam (Erasmus Universitair Medisch Centrum) departmental fundsFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1157318NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1243121NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1S25817NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G.0A3116Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) WOG001420NInteruniversity Attraction Poles Grant IUAP/P7/07KU Leuven (Katholieke Universiteit Leuven) C12/16/023KU Leuven (Katholieke Universiteit Leuven) C14/19/095KU Leuven (Katholieke Universiteit Leuven) PF/10/014ZonMw (Netherlands Organisation for Health Research and Development) 2018/23115|ZONMW
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, features liver sinusoidal endothelial cell (LSEC) alterations with ill-defined driving factors. Zinc-Finger E-Box-binding Homeobox (ZEB)2 in LSECs preserves their specialized features, prevents capillarization and protects against liver fibrosis. To investigate a potential protective role against steatosis, the initial MASLD stage, we fed EC-specific Zeb2 knockout (EC
Indexed as
Endothelial CellsFatty LiverNon-alcoholic Fatty Liver DiseaseZinc Finger E-box Binding Homeobox 2AnimalsDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLMice, KnockoutZEB2 protein, mouseZinc Finger E-box Binding Homeobox 2CapillarizationLiver sinusoidal endothelial cellsMetabolic dysfunction-associated steatotic liver diseasePeroxisome Proliferator-Activated receptor alphaZinc-finger E-Box-binding Homeobox 2
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