Evidence map›Paper›PMID 40603961›Full record

ArticleScientific reports2025

The neutrophil-to-lymphocyte ratio is associated with increased risk of all-cause mortality in obstructive sleep apnea.

Xue-Jun Lin, Xu-Qiao Mei, Chu-Dan Yang, Yan-Qin Qiu, Bai-Ling Chen, Feng-Li Tang, Liang-Ji Zhang, Li Lin, Shi-Chao Wei, Li-Da Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xue-Jun Lin *Department of Laboratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Xu-Qiao Mei *Department of Laboratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Chu-Dan Yang *Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China.
Yan-Qin QiuDepartment of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China.
Bai-Ling ChenDepartment of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China.
Feng-Li TangDepartment of Medical Psychology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China.
Liang-Ji ZhangDepartment of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China.
Li LinDepartment of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China.
Shi-Chao WeiDepartment of Sleep Center, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian Province, China.
Li-Da ChenDepartment of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, China. 361328175@qq.com.

Funding

Natural Science Foundation of Fujian Province 2022J011474Young people training project from Fujian Province Health Bureau 2022GGA053
6 · The paper itself

Abstract

The association between neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, and all-cause mortality among individuals with obstructive sleep apnea (OSA) remains unclear. This study aimed to evaluate the association of NLR with all-cause mortality among individuals with OSA. A total of 4,085 participants with OSA were selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2008, with follow-up data collected until December 31, 2019. Weighted Cox regression analyses were used to explore the association between the NLR and all-cause mortality. Nonlinear associations were detected using restricted cubic splines (RCS). Subgroup analyses were further performed to explore these relationships. The mean follow-up time for the entire cohort was 137.7 months. There was a clear trend of increasing mortality risk with higher NLR quartiles, rising from 11.86% in Q1, 13.41% in Q2, 14.81% in Q3, to 29.22% in Q4. The Cox regression analysis revealed that lnNLR was associated with an increased risk of all-cause mortality after full adjustment (hazard ratio [HR] = 1.81, 95% CI 1.43-2.30, p < 0.001). RCS showed a J-shaped relationship between lnNLR with all-cause mortality (p-non-linear < 0.001). The interaction tests found that coronary heart disease (CHD) influenced the association between lnNLR and all-cause mortality, with a HR of 3.98 for those with CHD and 1.62 for those without CHD (p = 0.008). There was a nonlinear correlation between elevated NLR and increased risk of all-cause mortality among OSA individuals. The association was more pronounced among CHD subgroups. Future research should explore the underlying mechanisms and evaluate whether therapies targeting inflammation can lower mortality risk in OSA patients.

Indexed as

LymphocytesNeutrophilsSleep Apnea, ObstructiveAdultAgedFemaleHumansMaleMiddle AgedNutrition SurveysProportional Hazards ModelsRisk FactorsAll-cause mortalityNational health and nutrition examination surveyNeutrophil-to-lymphocyte ratioObstructive sleep apnea

Identifiers

PMID40603961
PMCPMC12223176

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.