SynthesisScientific reports2025
A systematic review and meta-analysis on the efficacy of postoperative radiotherapy after gross total resection of intracranial solitary fibrous tumors.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Intracranial solitary fibrous tumor with multiloculated cystic change: A case report.Radiology case reports · 2026Article
- Carbon-Ion Radiation Therapy for Unresectable Solitary Fibrous Tumor of the Intermediate Category: A Nationwide Multi-institutional Observational Study by the Japan Carbon-Ion Radiation Oncology Study Group.Advances in radiation oncology · 2026Article
- CD34 and p16 expression in central nervous system solitary fibrous tumors: an exploratory clinicopathologic study.Journal of neuro-oncology · 2026Article
- Long-term control of grade 3 intracranial solitary fibrous tumor achieved with pazopanib and stereotactic radiotherapy: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Advances in the multimodal management of central nervous system solitary fibrous tumors.Frontiers in oncology · 2026Review
- Case Report: Giant communicating solitary fibrous tumor of the temporal skull base and infratemporal fossa.Frontiers in surgery · 2026Article
- Editorial: Rare and misdiagnosed neurosurgical conditions volume II.Frontiers in surgery · 2025Article
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Authors and funding
14 authors.
Funding
Abstract
The efficacy of postoperative radiotherapy (PORT) after gross total resection (GTR) for intracranial solitary fibrous tumors (SFT) remains unclear due to the inconsistent results of previous studies, with some studies suggesting improved outcomes in progression-free survival (PFS) and overall survival (OS), while others report no significant benefit. Therefore, by evaluating and synthesizing data from relevant studies, we aimed to investigate the role of PORT, as compared with surgery alone, in survival outcomes after GTR of intracranial SFT. A systematic literature search, adhering to PRISMA guidelines and using Medline, Embase, and the Cochrane Library to identify relevant literature. The outcomes of interest included progression-free survival (PFS), overall survival (OS), and metastasis-free survival (MFS) at 3, 5, and 10 years, respectively. Differences between the two cohorts (GTR + PORT vs. GTR only) were estimated by calculating the hazard ratios. Twelve studies, including data from 419 patients (GTR + PORT, n = 225 vs. GTR, n = 194), were selected for meta-analysis. Pooled hazard ratios revealed that the PORT cohort showed sustained superiority in both PFS and OS compared with the surgery-only cohort after GTR of the tumor. These results were consistent with those of a subgroup analysis that focused on grade 2 and 3 intracranial SFT. However, no significant improvement was observed in MFS with PORT addition. This study underscores the importance of PORT in enhancing the PFS and OS of patients with intracranial SFT after GTR. These findings suggest that PORT should be considered an effective treatment strategy for all patients with intracranial SFT, irrespective of the extent of resection.
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