Evidence map›Paper›PMID 40603897›Full record

ArticleScientific reports2025

Disruption of small intestinal mucosal homeostasis in mice with amiodarone induced steatohepatitis.

Shoji Kawauchi, Sayo Horibe, Toru Tanaka, Naoto Sasaki, Junichi Kunimasa, Yoshiyuki Rikitake

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shoji KawauchiLaboratory of Pharmacy Practice, Comprehensive Education and Research Center, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe, 658-8558, Japan. skawauch@kobepharma-u.ac.jp.
Sayo HoribeLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1, Motoyamakitamachi, Higashinada-ku, Kobe, 658-8558, Japan.
Toru TanakaLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1, Motoyamakitamachi, Higashinada-ku, Kobe, 658-8558, Japan.
Naoto SasakiLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1, Motoyamakitamachi, Higashinada-ku, Kobe, 658-8558, Japan.
Junichi KunimasaKobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe, 658-8558, Japan.
Yoshiyuki RikitakeLaboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1, Motoyamakitamachi, Higashinada-ku, Kobe, 658-8558, Japan.

Funding

JSPS KAKENHI 20K16063
6 · The paper itself

Abstract

In the current study, we sought to investigate the pathogenesis of amiodarone (AMD)-induced steatohepatitis, focusing on the pathological changes in the small intestine and liver. The association between patients taking AMD and metabolic dysfunction-associated steatohepatitis (MASH) was analyzed using the Japanese Adverse Drug Event Report (JADER) database. Barrier functions, such as crypt-villus architecture, mucosal permeability, and intestinal microbiota composition, were analyzed in a mouse model of AMD-induced steatohepatitis. The JADER database revealed positive signals for MASH in patients taking AMD. AMD induced lipid accumulation and inflammation, Tnf mRNA expression, and F4/80

Indexed as

AmiodaroneFatty LiverHomeostasisIntestinal MucosaIntestine, SmallAnimalsDisease Models, AnimalGastrointestinal MicrobiomeHumansLiverMaleMiceMice, Inbred C57BLWnt Signaling PathwayAmiodaroneDrug-induced MASHGut–liver axisIntestinal microbiotaJADERWnt/β-catenin signaling pathway

Identifiers

PMID40603897
PMCPMC12223285

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.