Evidence map›Paper›PMID 40603861›Full record

ArticleNature communications2025

A single main-chain hydrogen bond required to keep GABA

Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genetic and pharmacological evidence linking CB1R signaling to hippocampal GABAergic dysfunction in ASD mouse model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cecilia M BorgheseDepartment of Neuroscience, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-1028-8277
Jason D GalpinDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-1923-5312
Samuel Eriksson LidbrinkDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0009-0008-4290-0177
Yuxuan ZhuangDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4390-8556
Netrang G DesaiDepartment of Neuroscience, University of Texas at Austin, Austin, TX, USA.
Rebecca J HowardDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2049-3378
Erik LindahlDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2734-2794
Christopher A AhernDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-7975-2744
Marcel P Goldschen-OhmDepartment of Neuroscience, University of Texas at Austin, Austin, TX, USA. marcel.goldschen-ohm@austin.utexas.edu.ORCID http://orcid.org/0000-0003-1466-9808

Funding

Chemical biology of voltage-gated cation channelsR35GM148239 · NIGMS · UNIVERSITY OF IOWA · PI Christopher A Ahern · 2023 to 2026
$2.5M
Mechanisms of stepwise activation and drug-modulation in ligand-gated ion channels.R01GM148591 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI GOLDSCHEN-OHM, MARCEL PAZ · 2022 to 2025
$1.3M
NIGMS NIH HHS R01 GM148591NIGMS NIH HHS R35 GM148239U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM148591U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM148239Vetenskapsrådet (Swedish Research Council) 2019-02433Vetenskapsrådet (Swedish Research Council) 2021-05806
6 · The paper itself

Abstract

GABA

Indexed as

Ion Channel GatingReceptors, GABA-AAnimalsgamma-Aminobutyric AcidHEK293 CellsHumansHydrogen BondingModels, MolecularMutationProtein Subunitsgamma-Aminobutyric AcidProtein SubunitsReceptors, GABA-A

Identifiers

PMID40603861
PMCPMC12222489

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.