ArticleNature communications2025
Hippocampal ripples predict motor learning during brief rest breaks in humans.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Hippocampal skill memory expansion drives online performance dynamics during skill learning.Cell reports · 2026Article
- Early skill learning is shaped by the offline emergence of expert synergies.Current biology : CB · 2026Article
- Neural Correlates of Motor Sequence Learning and Enhanced Offline Consolidation in 7-11-Year-Old Children.Human brain mapping · 2026Article
- Skill Memory Expansion Shapes Micro-Scale Dynamics of Skill Learning.bioRxiv : the preprint server for biology · 2026Article
- Histamine shapes the neurocomputational dynamics of human learning.Nature communications · 2026Article
- Perceptual Temporal Structure Supports Rhythm Learning and Enhances Theta Oscillations When Perception and Action Are Dissociated.Brain sciences · 2026Article
- Post-Learning Offline Pauses Support Consolidation Beyond the Mind-Wandering State.Clocks & sleep · 2026Article
- Expert Motor Synergies Emerge Predominantly Offline During Early Skill Learning.bioRxiv : the preprint server for biology · 2026Article
- Distinct roles of brain network flexibility in motor learning across age.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Micro-offline gains do not reflect offline learning during early motor skill acquisition in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Impaired Online and Enhanced Offline Motor Sequence Learning in Individuals with Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Critical aspects of motor learning and memory happen offline, during both wake and sleep. When healthy young people learn a motor sequence task, most of their performance improvement happens not while typing, but offline, during interleaved rest breaks. In contrast, the performance of patients with dense amnesia due to hippocampal damage actually gets worse over the rest breaks and improves while typing. These findings indicate that an intact hippocampus is necessary for offline motor learning during wake, but do not specify its mechanism. Here, we studied epilepsy patients (n = 17) undergoing direct intracranial electroencephalographic monitoring of the hippocampus as they learned the same motor sequence task. Like healthy young people, they show greater speed gains across rest breaks than while typing. They also show higher hippocampal ripple rates during these rest breaks that predict offline gains in speed. This suggests that motor learning during brief rest breaks during wake is mediated by hippocampal ripples. These results expand our understanding of the role of hippocampal ripples beyond declarative memory to include enhancing motor procedural memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.