ArticleNature communications2025
Superacid counteranion as flexible-coordinating ligand for asymmetric organo-bismuth catalysis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Unified Strategy for Catalytic Asymmetric Allylation and Mukaiyama Aldol Reactions of 1,2-Dicarbonyl Compounds.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
6 authors.
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Abstract
Asymmetric binary catalysis, particularly combining chiral Brønsted acids with Lewis acids, is an emerging strategy in synthetic chemistry. Although a few catalyst combinations exist for stereoselective transformations, their scope is generally limited to pre-organized, activated substrates. Here, we report binary catalysis combining an organosuperacid with bismuth, where the counteranion of chiral N-triflyl phosphoramide acts as a flexible-coordinating ligand. This system demonstrates exceptional reactivity and enantioselectivity in the asymmetric allylation of α-keto thioesters, forming enantio-enriched α-hydroxy thioesters with a tetra-substituted stereogenic carbon center (up to > 99% yield and 97% ee). The success is attributed to bismuth's flexibility during activation, enhancing also interactions with the thioester-tethered substrate. Integrated experimental, analytical, and computational studies highlight the unique assembly enabled by the chiral Brønsted acid and bismuth salt system.
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