Evidence map›Paper›PMID 40603823›Full record

ArticleNeurocritical care2025

Dynamic Impact of Leptomeningeal Collateral Status for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke with Endovascular Treatment: A Prospective Study.

Xin Jiang, Tingting Guo, Yidie Lin, Yanbo Li, Yaowen Hu, Xin He, Ning Chen, Muke Zhou, Jian Guo

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Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin Jiang *Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tingting Guo *Department of Neurology, Genertec Medical Chengfei Hospital, Chengdu, Sichuan, China.
Yidie LinDepartment of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yanbo LiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yaowen HuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xin HeDepartment of Neurology, West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan, China.
Ning ChenDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Muke ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jian GuoDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. jian_guo@scu.edu.cn.

Funding

Chengdu Health Bureau project 2024029Key Research and Development Program of Sichuan Province 2024YFFK0317Science and Technology Department of Sichuan Province 2023NSFSC1562
6 · The paper itself

Abstract

backgroundHemorrhagic transformation (HT) remains a common and serious complication after endovascular treatment (EVT) for acute ischemic stroke (AIS). Limited data exist on how dynamic status of leptomeningeal collaterals influence HT in AIS. This study aims to investigate the impact of dynamic status of leptomeningeal collaterals on postoperative HT in patients with AIS undergoing EVT.

methodsA prospective cohort study was performed between January 2019 and June 2023. Only patients with middle cerebral artery occlusion who received EVT were included. Preoperative leptomeningeal collaterals were evaluated using the regional leptomeningeal collateral (rLMC) score, and postoperative collaterals were assessed using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology score.

resultsA total of 342 patients with middle cerebral artery occlusion were included in this study. Multivariate analysis demonstrated that patients with good rLMC scores (˃ 10) experienced fewer HT events compared with those with poor rLMC scores (≤ 10) (adjusted odds ratio [aOR] 0.46, 95% confidence interval [CI] 0.28-0.76, P = 0.002). Further subgroup analysis based on intravenous thrombolysis showed that good leptomeningeal collaterals were significantly associated with reduced risk of HT in patients receiving bridging therapy (aOR 0.12, 95% CI 0.03-0.38, p < 0.001). Among 75 patients with incomplete recanalization, analysis of collateral changes indicated that patients with consistently good preoperative and postoperative collateral had the lowest risk of HT (aOR 0.19, 95% CI 0.04-0.95, P = 0.043). However, no significant correlation was detected between symptomatic intracranial hemorrhage and preoperative and postoperative collateral or its dynamic evolution.

conclusionsGood preoperative leptomeningeal collateral status is associated with reduced risk of HT and better 90-day functional outcomes after EVT, possibly due to its role in maintaining cerebral perfusion and slowing infarct growth. Although our findings suggest that collateral-dependent infarct growth may be a potential mechanism for HT and unfavorable outcomes, this hypothesis requires further investigation.

Indexed as

Cerebral HemorrhageCollateral CirculationEndovascular ProceduresInfarction, Middle Cerebral ArteryIntracranial HemorrhagesIschemic StrokeMeningesAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesAcute ischemic strokeCollateral statusEndovascular treatmentHemorrhagic transformation

Identifiers

PMID40603823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.