ReviewAdvances in experimental medicine and biology2025
Iron and the Intestinal Microbiome.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does micronutrient supplementation improve outcomes in adult gastrointestinal surgery patients? A systematic review.Frontiers in nutrition · 2025Pooled it
- Gut microbiome and metabolic health: mechanisms and precision interventions.Gut microbes · 2026Review
- Gut microbiota and iron deficiency anemia: Mechanisms, microbial signatures, and dietary interactions (A narrative review).Asia Pacific journal of clinical nutrition · 2026Review
- High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Gut microbiota in anemia: mechanistic insights into iron metabolism, vitamin synthesis, and immune regulation.Frontiers in immunology · 2026Review
- Hyperferritinemia Is Associated with Higher Adiposity, Metabolic Syndrome, and Hepatic Dysfunction, Mainly Affecting Men: A Study in Southern Brazil.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Iron in the gut is like a double-edged sword. On one side, it is essential for numerous physiological processes, including oxygen transport and energy production, and is crucial for addressing conditions like anemia. However, on the other side, excess or unabsorbed iron can disrupt gut homeostasis, fuel harmful pathogens, contribute to dysbiosis, and promote gut inflammation. The challenge lies in finding a balance that ensures adequate iron absorption while minimizing its adverse effects on the gut microbiota. Host and microbiota in the gut have evolved sophisticated strategies to maintain iron homeostasis within the bacterial community and balance iron needs between host and gut microbiota. Disruption of this balance by excess iron could lead to serious consequences by promoting intestinal inflammation and disease progression. Current research points to promising therapeutical approaches that enhance iron absorption while suppressing iron-induced adverse effects, such as oxidative stress and dysbiosis, in the gut. These strategies offer the potential to reduce intestinal inflammation and improve gut health, paving the way for more effective therapies to mitigate disease complications.
Indexed as
Identifiers
40603801What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.