ReviewAdvances in experimental medicine and biology2025
Iron, Hepcidin, and Immunity.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation.European journal of immunology · 2026Article
- Reexamining the Role of Amyloid β Clearance from the Brain: Exporting Labile Iron from the Interstitial Fluid Performs a Protective Function.International journal of molecular sciences · 2026Review
- Dietary and nutritional supplementation strategies for table tennis athletes: a mini-review.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection involves the utilization of host nutritional resources by the pathogen. Genetic, experimental, and clinical evidence supports the critical role of iron as a focus for both pathogen attack and host defense. The molecular basis of how mammals regulate iron transport to maintain homeostasis, and in response to infection, has been well characterized since the discovery of the hormone hepcidin. The multiple activities of iron in host innate and adaptive immune cell function have also been studied in increasing depth. Recently these research strands have been converging, showing how host regulation of iron affects not only classical "nutritional immunity" as a defense against pathogens but also influences the development and magnitude of immune responses. These findings are discussed in the context of different types of infectious micro-organisms, against a background of host disease states (including respiratory disorders), and in relation to iron supplementation, vaccination, and pathological immune responses.
Indexed as
Identifiers
40603793What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.