Evidence map›Paper›PMID 40603785›Full record

ReviewAdvances in experimental medicine and biology2025

Dietary Iron Absorption: Biochemical and Nutritional Aspects.

David M Frazer, Gregory J Anderson, James F Collins

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David M FrazerQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Gregory J AndersonQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. greg.anderson@qimrberghofer.edu.au.
James F CollinsFood Science & Human Nutrition Department, University of Florida, Gainesville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential nutrient for most organisms; however, it can also be toxic when present in excess. For this reason, life has evolved complex pathways to tightly control the amount of iron contained within body tissues. Unlike most other nutrients, mammals do not have a regulated excretory mechanism for iron and, therefore, must regulate body iron levels at the point of dietary iron absorption in the proximal small intestine. In this chapter, we will describe the molecules and pathways involved in this important process, including our current understanding of the mechanisms of both heme and non-heme iron absorption. The regulation of this process will also be discussed, with particular emphasis on local and systemic factors that affect how much iron is absorbed from the diet. We also highlight areas where our knowledge is incomplete and where more research is required to fully understand the molecular mechanisms responsible for this essential process.

Indexed as

Intestinal AbsorptionIronIron, DietaryAnimalsHemeHumansIntestine, SmallHemeIronIron, DietaryDivalent metal-ion transporter 1FerroportinHeme ironHepcidinIron absorption

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.