Evidence map›Paper›PMID 40603784›Full record

ReviewAdvances in experimental medicine and biology2025

Iron and Cell Death.

Giorgia Federico, Marialuisa Moccia, Francesca Carlomagno

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giorgia FedericoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, Napoli, Italy.
Marialuisa MocciaIstituto di Endocrinologia e Oncologia Sperimentale del CNR, Napoli, Italy.
Francesca CarlomagnoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, Napoli, Italy. francesca.carlomagno@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential micronutrient that supports cellular pathways such as DNA replication, metabolism, oxygen transport and oxidative phosphorylation via reduction-oxidation reactions. Nevertheless, in specific conditions, iron can be deleterious since it promotes different types of unprogrammed and programmed cell death, including apoptosis, necroptosis, and ferroptosis. In this chapter, we will address the role of iron in promoting cell death and the signaling pathways involved.

Indexed as

ApoptosisCell DeathFerroptosisIronNecroptosisAnimalsHumansSignal TransductionIronApoptosisFerroptosisNecroptosisNFR2ROS

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.