ReviewAdvances in experimental medicine and biology2025
Systemic Iron Metabolism.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The neogenin-hemojuvelin axis in murine liver is crucial for hepcidin expression.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Ferritin Iron Mineralisation: Route of FeAngewandte Chemie (International ed. in English) · 2026Article
- Iron Metabolism in the Colorectal Tumor Microenvironment: Current Evidence and Clinical Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Iron Metabolism in the Colorectal Tumor Microenvironment: From Preneoplastic Lesions to Cancer Progression.International journal of molecular sciences · 2026Review
- Interplay of Total Antioxidant Capacity and Oxidative Stress Hydroperoxides with Circulating Biomarkers of Inflammation and Iron Status According to Oral Contraception Use.Antioxidants (Basel, Switzerland) · 2026Article
- Vitamin B6 deficiency anemia resembles iron-deficiency anemia but does not activate intestinal HIF2⍺.Experimental hematology · 2026Article
- Darbepoetin alfa is more effective than epoetin-β in suppressing hepcidin and improving iron utilization in maintenance hemodialysis patients.American journal of translational research · 2026Article
- Serum ferritin change rate combined with a multidimensional inflammation model for predicting efficacy and survival in extensive-stage small-cell lung cancer patients undergoing immunotherapy: a single-center, retrospective cohort study.Frontiers in immunology · 2026Article
- Ferroptosis in liver diseases: molecular mechanisms, biomarker potential, and clinical translation.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron, a versatile electron donor and acceptor, is essential for life as a component of enzymes and oxygen transporters but also has the potential to cause toxicity when in excess. Its dietary absorption as well as plasma and tissue concentrations are subject to close regulation, systemically coordinated by the interaction of the hepatic peptide hormone hepcidin and its cellular receptor, the iron exporter ferroportin. Ferroportin mediates the delivery of iron to plasma from absorptive enterocytes, from macrophages that digest senescent erythrocytes, and from iron-storing hepatocytes. Hepcidin inhibits the transport of iron into plasma by occluding ferroportin and inducing its endocytosis and proteolysis. The production of hepcidin is feedback-regulated by the concentration of extracellular iron, as well as by the amount of iron in hepatic storage. Hepcidin production is also modulated by erythroid regulators (e.g., erythroferrone) that act to match the supply of iron to the fluctuating requirements of hemoglobin synthesis and erythropoiesis. During infections, hepcidin is induced by IL6 and restricts the growth of invading microorganisms by limiting the production of non-transferrin-bound iron. Although many of the underlying molecular and cellular mechanisms have been elucidated through the study of human diseases and their laboratory models, substantial gaps remain to be filled by further investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.