ReviewAdvances in experimental medicine and biology2025
Cellular Iron Homeostasis.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Iron is an essential nutrient for all eukaryotic cells, yet it is potentially toxic. Cells have elegant systems coordinating the uptake, use, storage, and export of this metal while also responding to extracellular cues for regulating uptake and efflux. Here we describe the basic systems that operate in all cells with the goal of maintaining iron homeostasis in a highly dynamic system. In mammalian tissues and organs, multiple cell types are highly specialized in their iron management with the goal of maintaining cellular homeostasis subordinate to achieving a more specific function, e.g., dietary iron absorption in the intestinal epithelium, hemoglobin synthesis in the erythron, and iron recycling in splenic macrophages. The alterations in cellular iron balance that allow for these specializations will be briefly discussed.
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40603781What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.