Evidence map›Paper›PMID 40603776›Full record

Articlenpj metabolic health and disease2024

Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice.

Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Julica Inderhees, Olaf Jöhren, Jens Mittag, Henrik Oster

Abstract read
In one paragraph

Article in npj metabolic health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leonardo Vinicius Monteiro de AssisInstitute of Neurobiology, Center of Brain Behavior & Metabolism, University of Lübeck, Lübeck, Germany. leonardo.deassis@uni-luebeck.de.ORCID http://orcid.org/0000-0001-5209-0835
Lisbeth HarderInstitute of Neurobiology, Center of Brain Behavior & Metabolism, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-0637-720X
Julica InderheesBioanalytic Core Facility, Center of Brain Behavior & Metabolism, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0003-4523-3652
Olaf JöhrenBioanalytic Core Facility, Center of Brain Behavior & Metabolism, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-0532-5133
Jens MittagInstitute for Endocrinology and Diabetes-Molecular Endocrinology, Center of Brain Behavior & Metabolism, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0001-7778-5158
Henrik OsterInstitute of Neurobiology, Center of Brain Behavior & Metabolism, University of Lübeck, Lübeck, Germany. henrik.oster@uni-luebeck.de.ORCID http://orcid.org/0000-0002-1414-7068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol and triglyceride turnover, with thyroid hormone receptor beta (THRB) signaling playing a pivotal role. This study probed the potential interaction between THRB action and another critical regulator of liver energy metabolism, the circadian clock. Liver transcriptome analysis of THRB deficient (THRB

Identifiers

PMID40603776
PMCPMC12118710

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.