Evidence map›Paper›PMID 40603699›Full record

ArticleNpj imaging2025

Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis.

Chunxiang Zhang, Hua Ma, Daniel DeRoche, Eric M Gale, Pamela Pantazopoulos, Nicholas J Rotile, Himashinie Diyabalanage, Valerie Humblet, Peter Caravan, Iris Y Zhou

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Chunxiang ZhangAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hua MaAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daniel DeRocheAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Eric M GaleAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Pamela PantazopoulosAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nicholas J RotileAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Himashinie DiyabalanageCollagen Medical LLC, Boston, MA, USA.
Valerie HumbletCollagen Medical LLC, Boston, MA, USA.
Peter CaravanAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pcaravan@mgh.harvard.edu.
Iris Y ZhouAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. iris.zhou@mgh.harvard.edu.

Funding

Molecular MR Imaging of Hepatic FibrogenesisR01DK121789 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Peter D Caravan · 2019 to 2026
$5.0M
Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
Targeted Imaging of Fibrosis in the Left AtriumR44AG059524 · NIA · COLLAGEN MEDICAL, LLC · PI HUMBLET, VALERIE · 2018 to 2022
$1.8M
Console Upgrade for 4.7T PET-MRI Preclinical ScannerS10OD034258 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI FARRAR, CHRISTIAN T · 2023 to 2023
$600k
MRI-Compatible PET Insert for Small Bore ScannerS10OD023503 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2017 to 2017
$600k
Inductively Coupled Plasma Mass SpectrometerS10OD032138 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2022 to 2022
$598k
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
$325k
NIA NIH HHS R44 AG059524NIDDK NIH HHS R01 DK121789NIH HHS K25HL1448837NIH HHS R01DK121789NIH HHS R44AG059524NIH HHS S10 OD021768NIH HHS S10 OD023503NIH HHS S10 OD025234NIH HHS S10 OD028499NIH HHS S10 OD032138NIH HHS S10 OD034258
6 · The paper itself

Abstract

Liver fibrosis is a common pathway shared by all forms of progressive chronic liver disease. There is an unmet clinical need for noninvasive imaging tools to diagnose and stage fibrosis, which presently relies heavily on percutaneous liver biopsy. Here, we explored the feasibility of using a novel type I collagen-targeted manganese (Mn)-based MRI probe, Mn-CBP20, for liver fibrosis imaging. In vitro characterization of Mn-CBP20 demonstrated its high binding affinity for human collagen (K

Identifiers

PMID40603699
PMCPMC12118721

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.