Evidence map›Paper›PMID 40603617›Full record

ArticleSurgical endoscopy2025

Continuous assessment of tissue perfusion using quantitative indocyanine green fluorescence imaging during controlled hypo- and reperfusion.

Frederik Thørholm Andersen, Jacob Petersen, Alexander Emil Kaspersen, Mads Vikkelsø Pedersen, Gustav Singer, Mads Holst Aagaard Madsen, Morten Asp Vonsild Lund, J Michael Hasenkam, Troels Lading

Abstract read
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frederik Thørholm AndersenDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200, Aarhus N, Denmark. fta@clin.au.dk.ORCID http://orcid.org/0009-0000-5605-1673
Jacob PetersenDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200, Aarhus N, Denmark.
Alexander Emil KaspersenDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200, Aarhus N, Denmark.
Mads Vikkelsø PedersenPerfusion Tech ApS, Copenhagen, Denmark.
Gustav SingerPerfusion Tech ApS, Copenhagen, Denmark.
Mads Holst Aagaard MadsenPerfusion Tech ApS, Copenhagen, Denmark.
Morten Asp Vonsild LundPerfusion Tech ApS, Copenhagen, Denmark.
J Michael HasenkamDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200, Aarhus N, Denmark.
Troels LadingDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200, Aarhus N, Denmark.

Funding

The Eurostars Programme 1825
6 · The paper itself

Abstract

backgroundIndocyanine green fluorescence imaging (ICG-FI) is a novel tool for continuous assessment of tissue perfusion. However, consensus on the optimal methodology is lacking.  It was hypothesized that quantitative ICG-FI parameters based on continuous micro-dosing correlate with corresponding transit time flow measurements in the functional renal end artery.  This study aimed to examine the feasibility of continuous, quantitative ICG-FI for detecting perfusion changes (hypoperfusion, reperfusion) in porcine kidneys.

methodsRenal perfusion was assessed using continuous, quantitative ICG-FI under controlled renal artery flow adjustments (no, partial, full, partial, and no occlusion) in ten healthy female pigs. Four 0.008 mg/kg ICG micro-doses were administered with 60-s intervals for each flow adjustment. As a reference, simultaneous renal artery transit time flow probe measurements were recorded. ICG-FI parameters were extracted by PerfusionWorks

resultsDuring hypoperfusion, mean flow decreased from 277 to 139 to 0 ml/min in the no, partial, and full occlusion steps, respectively. F

conclusionContinuous assessment of renal perfusion was technically feasible. In this kidney model, the combined ICG-FI parameter, slope, and the intensity-dependent parameters F

Indexed as

Indocyanine GreenKidneyOptical ImagingRenal CirculationAnimalsFeasibility StudiesFemaleRenal ArteryReperfusionSwineIndocyanine GreenFluorescence imagingHypoperfusionIndocyanine greenKidneyPerfusionReperfusionTransit time flow measurements

Identifiers

PMID40603617
PMCPMC12287168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.