Evidence map›Paper›PMID 40603614›Full record

ArticleSurgical endoscopy2025

The new bridge to hernia surgery: achieving preoperative weight optimization with GLP-1 receptor agonists for abdominal wall hernia repair.

Graham J Spurzem, Ryan C Broderick, Patricia Ruiz-Cota, Amanda Rocha, Edgardo Reyes, Andres Fontaine-Nicola, Agustina Altolaguirre, Hannah M Hollandsworth, Bryan J Sandler, Eduardo Grunvald and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Graham J SpurzemDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA. gspurzem@health.ucsd.edu.ORCID http://orcid.org/0000-0002-1134-1754
Ryan C BroderickDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Patricia Ruiz-CotaDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Amanda RochaDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Edgardo ReyesDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Andres Fontaine-NicolaDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Agustina AltolaguirreDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Hannah M HollandsworthDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Bryan J SandlerDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.
Eduardo GrunvaldDivision of General Internal Medicine, Bariatric and Metabolic Institute, University of California San Diego, San Diego, CA, USA.
Garth R JacobsenDepartment of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, 9300 Campus Point Dr., La Jolla, San Diego, CA, 92037, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a risk factor for complications after abdominal hernia repair. Glucagon-like-peptide-1 (GLP-1) receptor agonists are effective weight loss medications that may help patients reach weight loss goals for surgery. In this study, we examine our outcomes utilizing GLP-1 agonists for preoperative weight loss in obese patients undergoing elective hernia repair.

methodsA retrospective review identified obese patients who were prescribed GLP-1 agonists for weight loss in addition to lifestyle changes before elective hernia repair from 2021 to 2024. Patients were managed by a multidisciplinary team and asked to achieve a body mass index (BMI) ≤ 33 kg/m

resultsA total of 70 patients with ventral/incisional, umbilical, parastomal, flank, and inguinal hernias were identified. 33 patients (47.1%) underwent surgery, 24 (34.3%) remain in active follow-up, and 13 (18.6%) were lost to follow-up (no clinic visit in 1 year). For patients who underwent surgery, mean BMI on initial presentation was 37.4 ± 4.8 kg/m

conclusionGLP-1 receptor agonists can facilitate expeditious and durable preoperative weight loss for patients with obesity prior to elective abdominal wall hernia repair with low postoperative morbidity.

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsHernia, AbdominalHerniorrhaphyObesityPreoperative CareAdultAgedBody Mass IndexElective Surgical ProceduresFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecurrenceReoperationGlucagon-Like Peptide-1 Receptor AgonistsAbdominal wall herniaGLP-1Glucagon-like peptide 1ObesityPrehabilitation

Identifiers

PMID40603614
PMCPMC12287229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.