ArticleNpj imaging2025
Noninvasive assessment of liver inflammation in metabolic dysfunction associated steatohepatitis using MR cytometry.
Article in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Repeatability of in vivo MR cytometry for measuring cell size and density in healthy human livers.Magnetic resonance imaging · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The current diagnostic gold standard for metabolic dysfunction-associated steatohepatitis (MASH) requires invasive biopsy to assess steatosis, inflammation, and ballooning. While MRI-based proton density fat fraction (PDFF) and MR elastography address steatosis and fibrosis, non-invasive methods for evaluating hepatic inflammation remain lacking. This study developed a diffusion MRI (dMRI)-based MR cytometry technique to map liver cellular properties, including MRI-derived cell size (excluding fat content) and cell density. Validation through histology-driven simulations and ex vivo MRI of fixed human liver specimens demonstrated that stromal regions exhibit smaller MRI-derived cell sizes and higher cell densities than both normal and fatty tissues. An in vivo feasibility study, conducted on healthy subjects (n = 5) and MASH patients (n = 5) using a clinical 3 T MRI system, further showcased the potential of MR cytometry to characterize pathological changes in liver microstructure.
Identifiers
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Registered trials
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