ArticleScientific reports2025
Antimicrobial, antibiofilm and antioxidant activities of bioactive secondary metabolites of marine Scarus ghobban gut-associated Aspergillus niger: In-vitro and in-silico studies.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Exploring Marinilactibacillus sp from Lake Urmia as a novel halophilic source of antibacterial bioactive compounds.Extremophiles : life under extreme conditions · 2026Article
- Isolation, characterization, and biological evaluation of endophytic fungi fromFrontiers in molecular biosciences · 2025Article
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6 authors.
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Abstract
Fungal extracts have garnered significant interest in recent years for their diverse applications in pharmaceutical field. This research focused on isolating fungi from the gut of Scarus ghobban for the first time and evaluate their biological activities Aspergillus niger was successfully isolated and identified using morphological and molecular techniques. Gas chromatography-mass spectrometry (GC-MS) analysis of the ethyl acetate extract (EA) of A. niger revealed eight compounds, with diisooctyl phthalate (54.32%) and 1,2-benzenedicarboxylic acid, bis (2-methoxyethyl) ester (26.32%) as the most abundant. High-performance liquid chromatography (HPLC) analysis identified catechol (15.41 µg/mL) and syringenic acid (13.25 µg/mL) as prominent phenolic compounds in the extract. The EA extract exhibited significant antibacterial activity toward pathogenic bacterial strains, with the highest inhibition zone (32 ± 0.1 mm) and minimum inhibitory concentration (MIC) of 7.8 µg/mL against Bacillus subtilis. Additionally, it showed antifungal activity against Candida tropicalis (MIC 7.8 µg/mL) and Candida albicans (MIC 31.25 µg/mL). The extract also demonstrated potential antibiofilm activity against Salmonella typhimurium, Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli, with inhibition percentages exceeding 87%. Moreover, it exhibited potent antioxidant activity IC50 8.17 µg/mL. Transmission electron microscopy revealed severe structural damage in B. subtilis, emphasizing the extract's antibacterial effectiveness and potential for therapeutic applications. Eventually, docking studies and computational calculations have been utilized to demonstrate the reactivity of the molecules. In conclusion, the ethyl acetate extract of A. niger from gut of S. ghobban demonstrates significant antibacterial, antibiofilm, and antioxidant activities, highlighting its potential as a valuable resource for developing effective antimicrobial agents and therapeutic applications.
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