ArticleScientific reports2025
Attribute based cross classification analyses from the BRIGHTEN study reveal that therapeutic responsiveness to erythropoiesis stimulating agents predicts cardiorenal prognosis in renal anemia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Nationwide attribute-based cross-classification reveals distinct risk patterns of major complications in ADPKD.Clinical and experimental nephrology · 2026Article
- Attribute-based cross-classification reveals sex- and age-specific prognostic impact of anemia in ADPKD.Clinical and experimental nephrology · 2026Article
- Association of anemia with long-term renal prognosis in autosomal dominant polycystic kidney disease using time-series analysis.Scientific reports · 2026Article
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7 authors.
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Abstract
Renal anemia outcomes are influenced by sex and age; however, current guidelines for renal anemia lack sex- or age-specific standards for initiating treatment. Recently, the concept of attribute-based medicine has gained attention, with an emphasis on personalized approaches based on patient characteristics. As prognostic factors for renal and cardiovascular outcomes may vary between men and women, as well as between younger and older patients with chronic kidney disease (CKD), we aimed to investigate anemia treatment-related indicators influencing kidney disease progression and cardiovascular events across four age and sex attributes (cross-classified by sex and age < or ≥ 65 years). A total of 1,671 patients with CKD and renal anemia from the BRIGHTEN study, who were initiated on an erythropoiesis-stimulating agent (ESA) according to Japanese guidelines for renal anemia recommending initiating treatment when the hemoglobin (Hb) level is 11 g/dL), were analyzed using the ESA resistance index-1B (ERI-1B) and the initial ESA response index (iEResI). Baseline Hb levels were similar across all sub-groups (9.7-9.9 g/dL), and kidney function was lowest in younger men (estimated glomerular filtration rate, 15.6 ml/min/1.73 m
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