ArticleScientific reports2025
Residential proximity to national priorities list superfund sites is associated with increased likelihood of metastatic breast cancer presentation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Residential proximity to Superfund sites and breast cancer incidence in a nationwide cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Genetic insights into the timing of metastasis: a secondary analysis of the Count Me In metastatic breast cancer cohort.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Breast cancer (BCa) is the most diagnosed female malignancy globally. While genetic and behavioral causes are known determinants of risk and stage at diagnosis, less is known about how environmental exposures influence etiology and progression. This study evaluates the association between National Priorities List (NPL) superfund site (SF) proximity and metastatic BCa presentation. The Florida Cancer Data System (FCDS) was used to source female BCa cases diagnosed between 2015 and 2019 with valid census tract identification numbers. NPL proximity was defined as ≥ one NPL site within census-designated place (CDP) of residence. Multivariable analyses were performed to assess association between SF proximity and increased odds of metastatic versus non-metastatic BCa presentation. 21,505 BCa cases were obtained. Mean age was 62 ± 14 years. Most patients were White (79%), non-Hispanic (62.7%), and had non-metastatic disease (93.6%). 10.1% of patients resided in CDPs with ≥ one SF. On multivariable analysis adjusting for age, race, ethnicity, and insurance type, living proximal to ≥ one SF was associated with 29% higher likelihood for metastatic versus non-metastatic disease (aOR 1.29; CI 1.08-1.59; p = 0.005); further adjustment for median income still resulted in a 27% higher likelihood (aOR 1.27; CI 1.06-1.51; p = 0.009). Living near NPL SF was associated with nearly 30% higher likelihood of metastatic versus non-metastatic BCa at the time of diagnosis. These findings suggest an etiologic role of environmental exposures in BCa and imply pollutants influence tumor biology and aggressiveness. Further research is warranted to histologically validate and explore underlying mechanisms.
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