Evidence map›Paper›PMID 40603294›Full record

ArticleNPJ microgravity2025

In space fabrication of Janus base nano matrix for improved assembly and bioactivity.

Anne Yau, Maxwell Landolina, Mari Anne Snow, Pinar Mesci, Brandon Williams, James B Hoying, Jana Stoudemire, Rayyanah Barnawi, Peggy Whitson, Rose Hernandez and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Anne Yau *Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Maxwell Landolina *Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Mari Anne SnowEascra Biotech Inc, Boston, MA, USA.
Pinar MesciAxiom Space, Houston, TX, USA.
Brandon WilliamsAxiom Space, Houston, TX, USA.
James B HoyingAdvanced Solution Life Sciences, Manchester, NH, USA.
Jana StoudemireAxiom Space, Houston, TX, USA.
Rayyanah BarnawiSaudi Space Agency, Riyadh, Saudi Arabia.
Peggy WhitsonAxiom Space, Houston, TX, USA.
Rose HernandezISS National Laboratory ® (ISS National Lab), Melbourne, FL, USA.
Derek DufloISS National Laboratory ® (ISS National Lab), Melbourne, FL, USA.
Honglu WuNational Aeronautics and Space Administration (NASA), Washington, DC, USA.
Yupeng ChenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. yupeng.chen@uconn.edu.

Funding

Supplement: Developing Nanomaterial Platform for Intra-Cartilage Delivery of RNA Therapeutics against Joint DiseasesR01AR072027 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI CHEN, YUPENG · 2017 to 2022
$2.3M
Computation-aided Molecular Design of DNA-Inspired Janus Base Biomaterials for Intracellular DeliveryR01GM155969 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI Yupeng Chen · 2024 to 2026
$1.2M
Layer-by-Layer Nano Matrix for Growth Plate RegenerationR21AR079153 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI CHEN, YUPENG · 2022 to 2023
$393k
NASA 80JSC022CA006National Science Foundation 2234570NIAMS NIH HHS R01 AR072027NIAMS NIH HHS R21 AR079153NIGMS NIH HHS R01 GM155969NIH HHS 7R01AR072027U.S. Department of Defense W81XWH2110274
6 · The paper itself

Abstract

Nanomaterials have a broad impact on both space and biomedical research but have never been produced in-space for regenerative applications. During the Axiom-2 (Ax-2) mission, our team completed the first-ever low Earth orbit (LEO) manufacturing of Janus base nanomaterials (JBNs) for cartilage tissue regeneration. This fabrication of JBNs in LEO resulted in superior product homogeneity, stability, and loading ability compared to Earth samples, demonstrating the benefits of manufacturing in microgravity.

Identifiers

PMID40603294
PMCPMC12222728

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.