ArticleRenal failure2025
Systemic immune-inflammatory biomarkers assist in differentiating clinical features of different etiologies of acute kidney injury: results from eICU Collaborative Research Database.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Predictors of In-Hospital Mortality and Incomplete Kidney Recovery in Patients with Cirrhosis-Associated Non-Hepatorenal Syndrome Acute Kidney Injury: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- A machine-learning-derived online prediction model based on inflammatory and nutritional composite indicators for acute kidney injury in sepsis patients with multiple myeloma.Frontiers in nutrition · 2026Article
- Linear association between the systemic immune-inflammation index and all-cause mortality in patients with interstitial lung disease: a retrospective cohort study.Frontiers in medicine · 2026Article
- The association between systemic immune-inflammation index and mortality of elderly chronic bronchitis patients complicated by acute myocardial infarction.Frontiers in cardiovascular medicine · 2026Article
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Abstract
backgroundThe relationship between distinct etiologies of acute kidney injury (AKI) and systemic immune-inflammatory biomarkers remains poorly defined.
methodsWe performed a retrospective cohort study utilizing the eICU Collaborative Research Database (eICU-CRD), a multicenter U.S. dataset. The study included all patients diagnosed with AKI while excluding those with unclear AKI etiology or chronic kidney disease. Analyzed variables encompassed demographic characteristics, admission/discharge data, laboratory parameters, severity scores, and comorbidities. We specifically evaluated four clinically accessible systemic immune-inflammatory indices. Intergroup differences were assessed using letter notations, nonlinear relationships were explored
resultsThe analysis included 2,912 patients with AKI of known etiology, categorized into six etiological subgroups. Pairwise comparisons revealed significant differences (
conclusionPatients with AKI primarily attributed to sepsis, ATN, or hepatorenal syndrome constitute a high-inflammation subgroup characterized by elevated systemic immune-inflammatory biomarkers. This subgroup independently predicts increased mortality risk.
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