Evidence map›Paper›PMID 40603177›Full record

ArticleJournal of cardiovascular computed tomography

Comparison of single-source cardiac CT and CMR quantified ventricular volumes and function in congenital heart disease.

Nikhil Patel, Jennifer Cohen, Hari G Rajagopal, David M Barris, Kenan W D Stern, Nadine F Choueiter, Kali A Hopkins, Gina LaRocca, Adam Jacobi, Barry Love and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nikhil PatelDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jennifer CohenDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hari G RajagopalDepartment of Pediatrics (Cardiology), Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, USA.
David M BarrisDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kenan W D SternDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nadine F ChoueiterDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kali A HopkinsDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gina LaRoccaMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adam JacobiDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Barry LoveDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert H PassDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ali N ZaidiDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Son Q DuongDepartment of Pediatrics (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: son.duong@mssm.edu.

Funding

Precision Prediction of Right Ventricular Size, Function, and Outcomes in Patients with Repaired Tetralogy of FallotK08HL173639 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Son Quang Duong · 2025 to 2026
$335k
NHLBI NIH HHS K08 HL173639
6 · The paper itself

Abstract

backgroundCardiac CT (CCT) is important for anatomic evaluation of congenital heart disease (CHD) prior to pulmonary valve replacement (PVR). However, volumetric and functional criteria for PVR are derived from cardiac MRI (CMR). Systematic differences between CCT and CMR volumes are underexplored in patients with CHD.

methodsRetrospective review of CHD patients with CMR and single-source CCT<180 days apart. Ventricular volumes were recontoured by blinded experts and global agreement was compared. Right ventricular regional differences in contours were assessed. Agreement of CCT with CMR-defined criteria for PVR was reported.

resultsTwenty-nine patients (mean age 33 years, 48 ​% tetralogy of Fallot, 24 ​% congenital pulmonary stenosis, 83 ​% evaluated for PVR) had average CMR RVEDVi 152 ​mL/m

conclusionsSingle-source CCT measures higher RV volumes and lower EF compared to CMR (i.e. more adversely-remodeled). Mechanisms include inferior stretch due to differences in breathing-instruction, and misidentification of end-systole. CMR-derived PVR thresholds applied to CCT would lead to more proactive intervention. "Adjusting" single-source CCT volumes by the observed difference between modalities is a reasonable approach. Single-source CCT-specific volumetric recommendations for PVR are needed.

Indexed as

Heart Defects, CongenitalHeart VentriclesMagnetic Resonance ImagingMagnetic Resonance Imaging, CineStroke VolumeVentricular Function, LeftVentricular Function, RightAdolescentAdultFemaleHumansMaleMiddle AgedObserver VariationPredictive Value of TestsReproducibility of ResultsCardiac CTCardiac MRICongenital heart diseasePulmonary valve replacementTetralogy of Fallot

Identifiers

PMID40603177
PMCPMC12278068

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.