Evidence map›Paper›PMID 40603132›Full record

SynthesisClinical breast cancer2025

Utilization and Fertility Preservation Outcomes in Women Undergoing Embryo Cryopreservation Before Breast Cancer Treatment: A Meta-Analysis.

Volkan Turan, Ozgur Oktem, Heejung Bang, Kutluk H Oktay

Abstract readMeta-Analysis
In one paragraph

Synthesis in Clinical breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. [Fertility management in breast cancer patients: current strategies and research advances].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Volkan TuranDepartment of Obstetrics and Gynecology, Istanbul Health and Technology University School of Medicine, Istanbul, Turkey; Innovation Institute for Fertility Preservation, Rye, NY.
Ozgur OktemDepartment of Obstetrics and Gynecology, Istanbul Koc University School of Medicine, Istanbul, Turkey.
Heejung BangDivision of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA.
Kutluk H OktayInnovation Institute for Fertility Preservation, Rye, NY; Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT. Electronic address: correspondence@fertilitypreservation.org.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Characterization & Prevention of Chemotherapy-Induced Damage to Ovarian ReserveR01HD053112 · NICHD · YALE UNIVERSITY · PI KUTLUK H OKTAY · 2007 to 2026
$7.6M
NCATS NIH HHS UL1 TR001860NICHD NIH HHS R01 HD053112
6 · The paper itself

Abstract

Our aim was to assess fertility preservation (the proportion of women who had at least 1 live birth) and utilization rates (the proportion of women who utilized their cryopreserved embryos) rates among women who cryopreserved their embryos before breast cancer treatments. PubMed and Cochrane library database were searched until December 2024. We included all studies that reported pregnancy outcomes, the number of women who returned for frozen embryo transfer, and the number of women who preserved their fertility. The primary outcome measures were the utilization and fertility preservation rates. Secondary outcome measures were implantation, clinical pregnancy, and live birth rates. Of the 12 studies, 9 met the criteria, encompassing >2126 women with breast cancer who cryopreserved their embryos for fertility preservation. In 9 studies that reported the total number of attempts, 424 women underwent 863 embryo transfers. Based on those studies, the clinical pregnancy and live birth rates were 50% (95% CI: 35-65, I

Indexed as

Breast NeoplasmsCryopreservationEmbryo TransferFertility PreservationFemaleHumansLive BirthPregnancyPregnancy OutcomePregnancy RateBreast cancerFertility preservationFrozen embryo transferLive birthPregnancy outcome

Identifiers

PMID40603132
PMCPMC12579529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.