Evidence map›Paper›PMID 40603100›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Coronavirus Disease 2019-associated Minimal Change Disease: Transient Improvement Does Not Preclude the Need for Standard Therapy in a Case Report and Review of the Literature.

Ryosuke Saiki, Kan Katayama, Enyo Akiyama, Tomohiro Murata, Kaoru Dohi

Abstract readCase ReportsReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryosuke SaikiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Kan KatayamaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Enyo AkiyamaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Tomohiro MurataDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Kaoru DohiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minimal change disease can be associated with coronavirus disease 2019 (COVID-19). We herein report a 38-year-old woman who developed biopsy-proven minimal change disease 5 days after COVID-19 infection. Initial observation showed some spontaneous reduction in proteinuria, which later worsened. Treatment with low-dose prednisolone (0.4 mg/kg/day) led to temporary improvement; however, relapse occurred upon tapering. Complete remission required addition of cyclosporine and rituximab. This case suggests that although COVID-19-associated nephrotic syndrome may initially improve post-infection, standard-dose immunosuppressive therapy may be necessary if complete remission is not achieved.

Indexed as

COVID-19Nephrosis, LipoidAdultCyclosporineFemaleHumansImmunosuppressive AgentsPrednisoloneRituximabSARS-CoV-2CyclosporineImmunosuppressive AgentsPrednisoloneRituximabcoronavirus disease 2019minimal change diseasenephrotic syndrome

Identifiers

PMID40603100
PMCPMC12900582

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.