Evidence map›Paper›PMID 40603094›Full record

ArticleInternal medicine (Tokyo, Japan)2026

X-linked Agammaglobulinemia First Diagnosed in Adulthood with Recurrent Pneumonia and Multiple Warty Skin Nodules.

Misaki Isawa, Yoshihisa Tokunaga, Masaki Tominaga, Hiroyoshi Yamada, Misa Sudou, Sakiko Sumita, Saeko Tokisawa, Kiyohito Okumiya, Keishirou Houjou, Kenji Gotoh and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Misaki IsawaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Yoshihisa TokunagaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Masaki TominagaDepartment of Community Medicine, Kurume University School of Medicine, Japan.
Hiroyoshi YamadaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Misa SudouDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Sakiko SumitaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Saeko TokisawaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Kiyohito OkumiyaDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Keishirou HoujouDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Kenji GotohDepartment of Infection Control and Prevention, Kurume University School of Medicine.
Ryuta NishikomoriDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Tomotaka KawayamaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Tomoaki HoshinoDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Toshiaki ManabeSakaimachi-Oike Pathology Clinic, Consultant, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 21-year-old man with a history of recurrent pneumonia and aggregated skin nodules on both legs was admitted to our hospital. His family history revealed an early death from unknown causes, which led us to suspect immune abnormalities. Laboratory tests showed markedly low B cell counts and serum IgG, IgA, and IgM levels, while his T-cell system appeared normal. Genetic testing revealed a Bruton Tyrosine Kinase gene variant, and the patient was diagnosed with X-linked agammaglobulinemia. The patient has recovered from all illnesses since receiving immunoglobulin replacement therapy and is currently doing well without any further infections.

Indexed as

AgammaglobulinemiaGenetic Diseases, X-LinkedPneumoniaWartsAgammaglobulinaemia Tyrosine KinaseHumansMaleRecurrenceYoung AdultAgammaglobulinaemia Tyrosine Kinasebacterial pneumoniaBruton Tyrosine KinaseimmunodeficiencyMalassezia folliculitisX-linked agammaglobulinemia

Identifiers

PMID40603094
PMCPMC12900604

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.