ArticleACS synthetic biology2025
Engineered Yeasts Displaying PETase and MHETase as Whole-Cell Biocatalysts for the Degradation of Polyethylene Terephthalate (PET).
Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biological Degradation of Phthalates: From Bioremediation to Plastic Waste Valorization.ChemSusChem · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to its low cost of manufacturing, poly(ethylene terephthalate) (PET, a polyester plastic) has been the most widely used plastic material for food packaging. However, PET is nonbiodegradable. It can take years to degrade when it is discarded into the environment. In recent years, plastic pollution has received much attention and has become a major environmental issue. In this study, we engineered yeast surfaces to display two PET-degrading enzymes (PETase and MHETase) to degrade PET plastics. The enzymes displayed on the yeast surface were characterized by using confocal microscopy and flow cytometry. The reaction conditions to degrade PET plastics using the engineered yeasts were optimal at pH 9 and 30 °C. In addition, the engineered yeasts showed great stability and reusability to degrade PET films. Furthermore, we demonstrated that the engineered yeasts as whole-cell catalysts can be used to degrade drinking water bottles into value-added products. This study provides a novel whole-cell biocatalyst using engineered yeasts to degrade plastic waste, offering a new strategy to solve plastic pollution and recycling challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.