Evidence map›Paper›PMID 40602758›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Pentagalloyl glucose inhibits monosodium urate-induced inflammation and NLRP3 inflammasome formation via TAK1.

Paul M Panipinto, Guihua E Yue, Bhagwat Prasad, Salahuddin Ahmed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paul M PanipintoDepartment of Pharmaceutical Sciences, Washington State University, College of Pharmacy and Pharmaceutical Science, Spokane, Washington, United States.ORCID 0000-0002-1072-899X
Guihua E YueDepartment of Pharmaceutical Sciences, Washington State University, College of Pharmacy and Pharmaceutical Science, Spokane, Washington, United States.
Bhagwat PrasadDepartment of Pharmaceutical Sciences, Washington State University, College of Pharmacy and Pharmaceutical Science, Spokane, Washington, United States.ORCID 0000-0002-9090-0912
Salahuddin AhmedDepartment of Pharmaceutical Sciences, Washington State University, College of Pharmacy and Pharmaceutical Science, Spokane, Washington, United States.ORCID 0000-0003-2526-8110

Funding

MicroRNA-based therapy for rheumatoid arthritisR01AR072615 · NIAMS · WASHINGTON STATE UNIVERSITY · PI AHMED, SALAH-UDDIN · 2018 to 2022
$1.9M
Pentagalloyl glucose as an inhibitor of monosodium urate induced inflammationF31AR081679 · NIAMS · WASHINGTON STATE UNIVERSITY · PI PANIPINTO, PAUL · 2022 to 2024
$53k
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR072615HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) F31AR081679NIAMS NIH HHS F31 AR081679NIAMS NIH HHS R01 AR072615
6 · The paper itself

Abstract

Monosodium urate (MSU)-induced inflammation is caused by the deposition of MSU crystals in the joints and periarticular tissues under conditions of hyperuricemia. These deposits can activate joint resident macrophages that form the NOD-, LRR-, and pyrin-containing protein 3 (NLRP3) inflammasome, cleaving pro-IL-1β and causing inflammation. The present study investigated the anti-inflammatory properties of a polyphenolic compound pentagalloyl glucose (PGG) in MSU-induced inflammation. Pretreatment of THP-1 monocyte-derived macrophages with PGG (0.1-10 µM) caused a dose-dependent inhibition of MSU-induced TAK1

Indexed as

Anti-Inflammatory AgentsGoutHydrolyzable TanninsInflammasomesInflammationMAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 ProteinUric AcidAnimalsHumansHyperuricemiaInterleukin-1betaMacrophagesMaleMAP Kinase Kinase Kinase 7MiceAnti-Inflammatory AgentsHydrolyzable TanninsInflammasomesInterleukin-1betaMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mousepentagalloylglucoseUric Acidgoutinterleukin-1NLRP3 Inflammasomepentagalloyl glucoseTAK1

Identifiers

PMID40602758
PMCPMC12318505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.