Evidence map›Paper›PMID 40602755›Full record

ArticleJournal of the American Chemical Society2025

Programmable Liposome Organization via DNA Origami Templates.

Zhao Zhang, Zhaomeng Feng, Xiaowei Zhao, Zhiheng Yu, Edwin R Chapman

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface.Journal of the American Chemical Society · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhao ZhangHoward Hughes Medical Institute, Department of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0002-1133-4191
Zhaomeng FengHoward Hughes Medical Institute, Department of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Xiaowei ZhaoHoward Hughes Medical Institute, CryoEM Shared Resource, Janelia Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, United States.
Zhiheng YuHoward Hughes Medical Institute, CryoEM Shared Resource, Janelia Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, United States.
Edwin R ChapmanHoward Hughes Medical Institute, Department of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0001-9787-8140

Funding

Synaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7M
Fusion pore structure and dynamicsR35NS136306 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2025 to 2026
$1.3M
NIMH NIH HHS R01 MH061876NINDS NIH HHS R35 NS136306
6 · The paper itself

Abstract

Liposomes are essential vehicles for membrane protein reconstitution and drug delivery, making them vital tools in both in vivo and in vitro studies. However, the lack of robust techniques for the precise arrangement of these synthetic vesicles limits their potential applications. Here, we present a modular polymerization platform based on square DNA origami to template the formation and organization of liposomes. By programming the sequence, number, position, chirality, and flexibility of sticky ends on each square, we assemble uniformly sized liposomes into diverse two-dimensional (2D) arrays, as well as finite lattices and rings. Additionally, we demonstrate stepwise assembly and targeted disassembly, enabling dynamic structural control. These complex liposome architectures represent a significant advancement in the fields of biotechnology, nanotechnology, and bottom-up biology.

Indexed as

DNALiposomesNucleic Acid ConformationDNALiposomes

Identifiers

PMID40602755
PMCPMC12272708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.