Evidence map›Paper›PMID 40602694›Full record

ArticleAmerican journal of preventive medicine2025

Association of Preconception and Prenatal Cannabis Use With Breastfeeding.

Kelly C Young-Wolff, Sara R Adams, Kenya J Homsley, Stacey E Alexeeff, Erica P Gunderson, Monique B Does, Deborah Ansley, Carley Castellanos, Erica Haley, Lyndsay A Avalos

Abstract read
In one paragraph

Article in American journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelly C Young-WolffDivision of Research, Kaiser Permanente Northern California, Pleasanton, California; Department of Psychiatry and Behavioral Sciences, Well Institute of Neurosciences, University of California San Francisco, San Francisco, California; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California. Electronic address: Kelly.c.young-wolff@kp.org.
Sara R AdamsDivision of Research, Kaiser Permanente Northern California, Pleasanton, California.
Kenya J HomsleyDepartment of Obstetrics and Gynecology, Kaiser Permanente, Oakland, California.
Stacey E AlexeeffDivision of Research, Kaiser Permanente Northern California, Pleasanton, California.
Erica P GundersonDivision of Research, Kaiser Permanente Northern California, Pleasanton, California; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.
Monique B DoesDivision of Research, Kaiser Permanente Northern California, Pleasanton, California.
Deborah AnsleyRegional Offices, Kaiser Permanente Northern California, Oakland, California.
Carley CastellanosRegional Offices, Kaiser Permanente Northern California, Oakland, California.
Erica HaleyCalifornia Polytechnic State University, San Luis Obispo, California.
Lyndsay A AvalosDivision of Research, Kaiser Permanente Northern California, Pleasanton, California; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.

Funding

Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort StudyR01DA047405 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI AVALOS, LYNDSAY AMMON, YOUNG-WOLFF, KELLY CORINNE · 2019 to 2023
$3.5M
Impact of in utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort StudyR01DA048033 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI AVALOS, LYNDSAY AMMON, YOUNG-WOLFF, KELLY CORINNE · 2020 to 2025
$3.1M
Modes of Cannabis Administration and Polysubstance Use among Women Before and During PregnancyR01DA058201 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Kelly Corinne Young-Wolff · 2023 to 2026
$2.6M
Identifying Risk Factors for Prenatal Substance and Polysubstance UseK01DA043604 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI YOUNG-WOLFF, KELLY CORINNE · 2017 to 2021
$907k
NIDA NIH HHS K01 DA043604NIDA NIH HHS R01 DA047405NIDA NIH HHS R01 DA048033NIDA NIH HHS R01 DA058201
6 · The paper itself

Abstract

introductionBreastfeeding is recommended. It is unknown whether preconception or prenatal cannabis use is related to breastfeeding behaviors.

methodsThis population-based retrospective cohort study included 200,207 pregnancies in Northern California (2016-2022) with live births screened in early pregnancy for cannabis use. Exposures included prenatal cannabis use, preconception cannabis use only, or no cannabis use. Additional analyses considered the frequency of prenatal cannabis use. Longitudinal breastfeeding outcomes assessed at each well-child visit during the first year included any breastfeeding and full breastfeeding (breastmilk without formula). Adjusted prevalence ratios were calculated using modified Poisson regression for longitudinal binary outcomes. Analyses were conducted in 2024 and 2025. The risk of stopping breastfeeding among those who started was modeled using Cox proportional hazard regression.

resultsOverall, 7.6% of pregnancies had preconception cannabis use only, and 7.2% had prenatal use. Most people (94.6% overall) initiated breastfeeding, with only modest differences by cannabis use (94.9% no cannabis use, 95.7% preconception cannabis use only, and 90.5% prenatal cannabis use). However, over time, prenatal cannabis use was associated with earlier discontinuation of breastfeeding (adjusted hazard ratio=1.12; 95% CI=1.09, 1.15) and lower prevalence of breastfeeding (adjusted prevalence ratio=0.84; 95% CI=0.82, 0.85 at 6 months and adjusted prevalence ratio=0.81; 95% CI=0.78, 0.83 at 12 months). Associations were stronger for higher-frequency use. There were small differences in breastfeeding between those with preconception cannabis use only and those with no use. Full breastfeeding results were similar.

conclusionsDespite high prevalence of breastfeeding initiation, prenatal cannabis use was associated with earlier breastfeeding discontinuation and lower prevalence at 6 and 12 months.

Indexed as

Breast FeedingMarijuana UsePreconception CareAdultCaliforniaFemaleHumansInfant, NewbornPregnancyRetrospective StudiesYoung Adult

Identifiers

PMID40602694
PMCPMC12604813

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.