Evidence map›Paper›PMID 40602382›Full record

ArticleThe American journal of tropical medicine and hygiene2025

A Case of Infection with Leptospires from Three Different Serovars During a Flood in the Philippines.

Yasutake Yanagihara, Toshiyuki Masuzawa, Masashi Shingai, Marumi Ohno, Toshiki Sekiya, Naoki Nomura, Tomomi Kawakita, Chimuka Handabile, Yuichi Koshiishi, Richard Obeng-Kyeremeh and 5 more

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In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yasutake YanagiharaDepartment of Immunology and Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Toshiyuki MasuzawaLaboratory of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Chiba, Japan.
Masashi ShingaiDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Marumi OhnoDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Toshiki SekiyaDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Naoki NomuraDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Tomomi KawakitaDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Chimuka HandabileDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Yuichi KoshiishiDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Richard Obeng-KyeremehDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Toshihiro ItoDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Mitsumasa SaitoDepartment of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Sharon Y A M VillanuevaDepartment of Medical Microbiology, College of Public Health, University of the Philippines Manila, Philippines.
Nina G GlorianiInstitute of Pathology, St. Luke's Medical Center, Quezon City, Philippines.
Hiroshi KidaDivision of Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptospirosis a significant and life-threatening zoonosis with global reach. If diagnosis and treatment are delayed, the infection may lead to fatal Weil's disease. In the Philippines, a 21-year-old man was admitted to the hospital with leptospirosis-like symptoms, including fever, myalgia, headache, anuria, jaundice, hemorrhage, skin rash, and diarrhea. Although he was immediately treated with penicillin G, the patient died shortly after admission. The serological test result was negative for Leptospira; however, three leptospires were isolated from the patient through selective cultivation under varying conditions. Microscopic agglutination tests and a phylogenetic analysis of the flaB gene encoding the flagellin subunit protein revealed that the isolates belonged to three different serovars, suggesting that the patient was simultaneously infected with at least three distinct Leptospira serovars. In this case report, we highlight the potential risk of multiple infections with leptospires in humans, a critical consideration for diagnosis and treatment strategies.

Indexed as

FloodsLeptospiraLeptospirosisFatal OutcomeHumansMalePhilippinesPhylogenySerogroupYoung Adult

Identifiers

PMID40602382
PMCPMC12410250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.