ArticleEuropean journal of obstetrics, gynecology, and reproductive biology2025
Associations of adverse childhood experiences (ACE) with pregnancy outcomes in people with cardiac disease.
Article in European journal of obstetrics, gynecology, and reproductive biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThough there is a growing fund of knowledge on how Adverse Childhood Experiences (ACEs) affect pregnancy, less is known about potential intergenerational effects to the fetus in high-risk pregnancies such as those with cardiac complications. This is critical since maternal cardiac disease is one of the most common causes of maternal mortality. This study investigates the associations between exposure to ACEs and perinatal outcomes in pregnant adults with cardiovascular disease.
methodsThis was a prospective cohort of pregnant individuals with cardiac disease who delivered at a single tertiary care institution from 2012 to 2022. Demographics, pregnancy complications, and neonatal outcomes from their first recorded pregnancy were abstracted from medical records. Perinatal outcomes, including preeclampsia, gestational diabetes, preterm delivery (<34 weeks), fetal growth restriction (FGR), 5-minute APGAR score < 8, small for gestational age (SGA) and intrauterine fetal demise (IUFD) were compared to ACE scores from validated ACE questionnaires using multivariable logistic regression models adjusting for BMI and chronic hypertension.
resultsOut of 323 people who met inclusion criteria, 113 (35 %) completed the ACE questionnaire. Of those, 54 % experienced at least one ACE, while 20 % experienced 4 or more. After adjusting for confounders, the odds of FGR increased by 30 % with each additional ACE (aOR: 1.30 (1.02 - 1.66); P = 0.03). There was one intrauterine fetal demise, which was among those who experienced 4 or more ACEs.
conclusionOur study showed that 1 in 2 pregnant people with cardiac conditions experienced ACEs and 1 in 5 experienced 4 or more ACEs. Having a greater number of ACEs was associated with FGR in our study, which highlights the potential benefit of screening for ACEs at prenatal visits. This study expands on the growing data showing an association between ACEs and adverse pregnancy outcomes.
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