ArticleJournal of veterinary internal medicine
Myocardial and Renal Renin-Angiotensin System Enzyme Activity in Dogs.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Characterization of the myocardial and renal renin-angiotensin system in normal cats and cats with hypertrophic cardiomyopathy.Journal of veterinary internal medicine · 2026Article
- Myocardial and Renal Renin-Angiotensin System Enzyme Activity in Dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundMethods to quantify the activity of the tissue renin-angiotensin system (RAS) are needed.
objectiveTo estimate myocardial and renal RAS enzyme activity in postmortem tissues. ANIMALS: Convenience sample of 15 purpose-bred laboratory dogs with experimental heartworm infection (Group 1) euthanized as part of an unrelated study and 22 client-owned dogs which died or were euthanized for any reason (Group 2).
methodsProspective study where myocardial and renal tissue samples were frozen within 20 min of euthanasia (Group 1) or during routine necropsy exam (Group 2). Homogenized tissues were incubated with spiked angiotensin I or II (AngII) under control and inhibitor conditions to assess relative enzyme contributions to AngII or angiotensin 1-7 formation. Freezing was delayed (2- or 7-h in Groups 1 and 2, respectively) in paired samples, to evaluate the effect of time to freezing on RAS enzyme activity.
resultsSamples were harvested within 20 min of euthanasia (Group 1) or a median of 21.9 h after death or euthanasia (Group 2). RAS enzymes were active in all samples. The median contribution of angiotensin-converting enzyme to AngII formation was greater than 88% in all tissues. The 90% confidence limits of the geometric mean of the ratio of the angiotensin production of paired samples in 10/14 (Group 1) and 16/19 (Group 2) experiments met equivalence requirements (lower bound > 0.8 and upper bound < 1.2). CONCLUSIONS AND CLINICAL IMPORTANCE: Renin-angiotensin system enzymes are present and active in canine myocardial and renal tissues for greater than 24 h postmortem.
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Registered trials
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