Evidence map›Paper›PMID 40601861›Full record

ArticleACS infectious diseases2025

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of

Emanuele Fabbrizi, Gebremedhin Solomon Hailu, A Ganesan, Rossella Fioravanti, Clemens Zwergel, Chiara Lambona, Sergio Valente, Giulia Fianco, Angela Iuzzolino, Daniela Trisciuoglio and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Benzodeazaoxaflavin Sirtuin Inhibitors InhibitACS infectious diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emanuele FabbriziDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Gebremedhin Solomon HailuSchool of Pharmacy, Mekelle University, Mekelle 0231, Ethiopia.
A GanesanSchool of Pharmacy, University of East Anglia, Norwich NR4 7TJ, U.K.ORCID 0000-0003-4862-7999
Rossella FioravantiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Clemens ZwergelDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-3097-0003
Chiara LambonaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-3415-4126
Sergio ValenteDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-2241-607X
Giulia FiancoInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome 00185, Italy.
Angela IuzzolinoInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome 00185, Italy.
Daniela TrisciuoglioInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome 00185, Italy.
Jonatan CaroliDepartment of Biology and Biotechnology, University of Pavia, Via Ferrata 9, Pavia 27100, Italy.
Andrea MatteviDepartment of Biology and Biotechnology, University of Pavia, Via Ferrata 9, Pavia 27100, Italy.ORCID 0000-0002-9523-7128
Cécile HäberliSwiss Tropical and Public Health Institute, University of Basel, 4002 Allschwil, Switzerland, 4001 Basel, Switzerland.
Jennifer KeiserSwiss Tropical and Public Health Institute, University of Basel, 4002 Allschwil, Switzerland, 4001 Basel, Switzerland.
Dante RotiliDepartment of Science, Roma Tre University of Rome, Viale Guglielmo Marconi 446, 00146 Rome, Italy.ORCID 0000-0002-8428-8763
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-9176-2382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Enzyme InhibitorsHistone DemethylasesSchistosoma mansoniTranylcypromineAnimalsHumansSchistosomiasis mansoniEnzyme InhibitorsHistone DemethylasesKDM1A protein, humanTranylcyprominecytotoxicityLSD1lysine demethylasesreduction of viabilityS. mansoni

Identifiers

PMID40601861
PMCPMC12340956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.