Evidence map›Paper›PMID 40601816›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025

Safety and efficacy of a lattice-tip catheter for ventricular arrhythmia ablation: the AFFERA Ventricular Arrhythmia Ablation Registry (AVAAR).

Frédéric Sacher, Andrea Sarkozy, Helmut Pürerfellner, Alexandra Steyer, Jonathan Lyne, Charlène Coquard, Romain Tixier, Nicolas Combes, Michel Haissaguerre, Michalis Efremidis and 19 more

Abstract readMulticenter Study
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Ventricular pulsed field ablation from bench to bedside: preclinical and clinical evidence from a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  2. Pooled it
  3. Pulsed field ablation for the interventional treatment of atrial fibrillation: a scientific statement of the European Heart Rhythm Association of the European Society of Cardiology, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Guideline
  4. Trial
  5. Review
  6. How early should we ablate ventricular tachycardia? From rescue to prevention in ischaemic VT.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Cardiac implantable electronic device malfunction after pulsed field ablation-insights from the MAUDE database.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Impact of catheter ablation on prognostic outcomes in electrical storm.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  17. Latest Advances and Ongoing Challenges in Pulsed Field Ablation.Arrhythmia & electrophysiology review · 2026
    Review
  18. Review
  19. Article
  20. Pulsed field ablation for ventricular tachycardia: are we there yet?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Frédéric SacherCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0001-8348-9320
Andrea SarkozyHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium.ORCID 0000-0001-6327-0487
Helmut PürerfellnerDepartment of Cardiology, Ordensklinikum Linz Elisabethinen, Linz, Austria.ORCID 0000-0002-8965-8495
Alexandra SteyerCardioangiologische Centrum Bethanien (CCB), Frankfurt, Germany.ORCID 0009-0007-5466-0118
Jonathan LyneDepartment of Pacing and Electrophysiology, Beacon Hospital, Dublin, Ireland.ORCID 0000-0002-0257-8629
Charlène CoquardCardiovascular Institute Paris-Sud (ICPS), Jacques Cartier Private Hospital, Massy, France.ORCID 0009-0009-3494-0707
Romain TixierCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0003-4093-0483
Nicolas CombesGeneral and Interventional Cardiology-Rhythmology, Clinic Pasteur, Toulouse, France.
Michel HaissaguerreCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0001-7644-6146
Michalis EfremidisDepartment of Electrophysiology and Pacing, Onassis Cardiac Surgery Center, Athens, Greece.
Josselin DuchateauCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0002-4367-1117
Victor Castro UrdaElectrophysiology Unit, Cardiology Service, Hospital Puerta de Hierro Majadahonda, Madrid, Spain.ORCID 0000-0002-8325-1379
Claire A MartinElectrophysiology Department, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.ORCID 0000-0002-4143-6308
Marc LemoineDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-3799-7962
Alejandro Carta BergazServicio de Cardiología, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Madrid, Spain.ORCID 0000-0003-4059-8230
Frank BogunCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0002-0391-7282
Nick LintonImperial College London, London, UK.ORCID 0000-0002-5712-849X
Nicolas DervalCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0002-6189-1308
Filip SchlosserDepartment of Arrhythmology/Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.ORCID 0009-0002-5106-4314
Thomas PambrunCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0001-6763-2350
Jan PetruDepartment of Cardiology, Na Homolce Hospital, Prague, Czech Republic.
Meleze HociniCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0002-7957-8766
Luigi PannoneHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium.ORCID 0000-0001-9769-1511
Martin MudrochDepartment of Cardiology, Na Homolce Hospital, Prague, Czech Republic.ORCID 0009-0001-4178-111X
Josef KautznerDepartment of Arrhythmology/Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.ORCID 0000-0002-1632-6182
Pierre JaisCardiac Arrhythmia Department, IHU Liryc, Univ. Bordeaux, INSERM 1045, CHU de Bordeaux, CMARY, ERN Guard Heart, REFER-RYTHMO Network, F33600 Bordeaux, France.ORCID 0000-0002-4700-7811
Tobias ReichlinDepartment of Cardiac Electrophysiology, Inselspital, University of Bern, Bern, Switzerland.ORCID 0000-0002-7197-8415
Petr NeužilDepartment of Cardiology, Na Homolce Hospital, Prague, Czech Republic.ORCID 0000-0003-4334-8165
Petr PeichlDepartment of Arrhythmology/Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.ORCID 0000-0002-5625-0071

Funding

French Government as part of the 'Investments in the Future' program managed by the National Research Agency ANR-10-IAHU-04Grant France 2030REFER-RYTHMO network
6 · The paper itself

Abstract

aimsThe feasibility and safety of the lattice-tip catheter for ventricular arrhythmia (VA) ablation in humans remain largely unknown. This study aimed to assess feasibility, safety profile as well as patient outcomes after VA ablation with a lattice-tip catheter in a multicentre European registry. METHODS AND

resultsAll 18 European centres using the AFFERA system in September 2024 agreed to participate. Clinical, procedural, and follow-up data (minimum 3 months) were systematically collected and analysed. A total of 126 patients (18% female; mean age 59 ± 16 years) underwent VA ablation using the lattice-tip catheter during the inclusion period. Ablation indications included ventricular tachycardia (VT) in 99, premature ventricular complexes (PVCs) in 23, and ventricular fibrillation (VF) in 4 patients. Major and minor acute complications were observed in 7 (6%) and 18 (14%) procedures, respectively. They included thrombo-embolic event (n = 2), major bleeding (n = 2), ventricular fibrillation induction (n = 1), tamponade due to epicardial access (n = 1), and cardiogenic shock due to prolonged VT mapping (n = 1). Within the first month post-procedure, three patients died [from multi-organ failure (n = 2) and sepsis (n = 1)], two had worsening heart failure, one myocardial infarction, one sepsis, and one major gastro-intestinal bleeding. After a mean follow-up of 5.6 ± 3.7 months, absence of recurrence was 78% for PVC, 70% for VT, and 100% for VF.

conclusionIn this complex population with refractory VA, ablation using the lattice-tip catheter appears feasible and relatively safe. In the absence of large, randomized trials, exhaustive registry is of key importance to ensure safety and efficacy of new catheter technologies.

Indexed as

Cardiac CathetersCatheter AblationTachycardia, VentricularVentricular FibrillationVentricular Premature ComplexesAgedEquipment DesignEuropeFeasibility StudiesFemaleHumansMaleMiddle AgedRecurrenceRegistriesTreatment OutcomeLattice-tip catheterPulsed field ablationSafetyVT ablation

Identifiers

PMID40601816
PMCPMC12418093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.