Evidence map›Paper›PMID 40601754›Full record

ArticleScience advances2025

Delving into LLM-assisted writing in biomedical publications through excess vocabulary.

Dmitry Kobak, Rita González-Márquez, Emőke-Ágnes Horvát, Jan Lause

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Evolution of Artificial Intelligence Adoption inOrthopaedic journal of sports medicine · 2026
    Article
  6. The rise of large language models and the direction and impact of US federal research funding.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Reply to Topaz and Bahl: Interpreting a post-2022 lexical shift in academic prose.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. AI will reorganize science. Will research remain a human enterprise?Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. On the makeup of high-impact reviews in ecology.Eco-Environment & Health · 2026
    Article
  17. Article
  18. Article
  19. Academic journals' AI policies fail to curb the surge in AI-assisted academic writing.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dmitry KobakHertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, Germany.ORCID 0000-0002-5639-7209
Rita González-MárquezHertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, Germany.ORCID 0009-0005-6840-7979
Emőke-Ágnes HorvátNorthwestern University, Evanston, 60208 IL, USA.ORCID 0000-0001-7709-1172
Jan LauseHertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases. Yet, many scientists use them for their scholarly writing. But how widespread is such LLM usage in the academic literature? To answer this question for the field of biomedical research, we present an unbiased, large-scale approach: We study vocabulary changes in more than 15 million biomedical abstracts from 2010 to 2024 indexed by PubMed and show how the appearance of LLMs led to an abrupt increase in the frequency of certain style words. This excess word analysis suggests that at least 13.5% of 2024 abstracts were processed with LLMs. This lower bound differed across disciplines, countries, and journals, reaching 40% for some subcorpora. We show that LLMs have had an unprecedented impact on scientific writing in biomedical research, surpassing the effect of major world events such as the COVID pandemic.

Indexed as

Biomedical ResearchLanguagePublicationsVocabularyWritingHumans

Identifiers

PMID40601754
PMCPMC12219543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.