Evidence map›Paper›PMID 40601738›Full record

ArticleScience advances2025

Loss of the

Benjamin Koleske, Courtney Schill, Saranathan Rajagopalan, Somnath Shee, Yazmin B Martinez-Martinez, Manish Gupta, Jessica Shen, William R Jacobs, William R Bishai

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Loss of the ESX-5 secretion locus inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Frontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin KoleskeCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-1479-218X
Courtney SchillCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-2841-7612
Saranathan RajagopalanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0003-2201-8028
Somnath SheeCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-9313-8559
Yazmin B Martinez-MartinezCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Manish GuptaCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8782-6096
Jessica ShenCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-0210-9347
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0003-3321-3080
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8734-4118

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
Esx5 secretome in TB and TB-HIV pathogenesis and immunityR01AI192152 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI WILLIAM Ramses BISHAI, WILLIAM Robert JACOBS · 2025 to 2026
$1.6M
NIAID NIH HHS R01 AI192152NIAID NIH HHS R37 AI026170NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptation, PhysiologicalAntigens, BacterialBacterial ProteinsGene Expression Regulation, BacterialGenetic LociMycobacterium tuberculosisTranscription, GeneticTuberculosisAnimalsMiceVirulenceAntigens, BacterialBacterial Proteins

Identifiers

PMID40601738
PMCPMC12219505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.