Evidence map›Paper›PMID 40601728›Full record

ArticleScience advances2025

Spatial-offset pump-probe imaging of nonradiative dynamics at optical resolution.

Guo Chen, Yuhao Yuan, Hongli Ni, Guangrui Ding, Mingsheng Li, Yifan Zhu, Deming Li, Hongru Zeng, Hongjian He, Zhongyue Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guo ChenDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-0239-0068
Yuhao YuanDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-0731-0127
Hongli NiDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-4323-1493
Guangrui DingDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Mingsheng LiDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Yifan ZhuDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-4421-1486
Deming LiDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Hongru ZengDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Hongjian HeDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Zhongyue GuoDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Ji-Xin ChengDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-5607-6683
Chen YangDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0001-9454-847X

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
Sensing Vulnerable Plaque in vivo by an All-optical Intravascular Ultrasound and Photoacoustic CatheterR01HL125385 · NHLBI · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2015 to 2023
$4.6M
Massively Parallel Optoacoustic Retinal Stimulation at Micrometer-ResolutionR21EY035437 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI YANG, CHEN · 2023 to 2025
$680k
Injectable Optoacoustic Retina ProsthesesR21EY036579 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI YANG, CHEN · 2024 to 2024
$589k
NEI NIH HHS R21 EY035437NEI NIH HHS R21 EY036579NHLBI NIH HHS R01 HL125385NIGMS NIH HHS R35 GM136223
6 · The paper itself

Abstract

Nonradiative photothermal (PT) and photoacoustic (PA) processes have found widespread applications in imaging, stimulation, and therapy. Mapping the generation and propagation of PA and PT waves with high resolution is important to elucidate the interaction between nonradiative fields and biological systems. To this end, we introduce spatial-offset pump-probe imaging (SOPPI). By spatially offsetting the pump beam and the probe beam, SOPPI allows simultaneous imaging of PA/PT wave propagation with nanosecond temporal resolution, micrometer spatial resolution, 65-megahertz detection bandwidth, and a sensitivity of 9.9-pascal noise equivalent pressure. First, the PA and PT evolution from a fiber emitter and the subsequent wave interaction with a mouse skull and brain slices are demonstrated. Then, using water as the absorber, a wavelength-dependent PA/PT generation, evanescent wave-generated PA, and a back-propagated acoustic Mach cone with a tapered fiber are recorded. At last, a SOPPI-PACT is developed to reconstruct the pigment distribution inside a zebrafish larva with high precision and signal-to-noise ratio.

Identifiers

PMID40601728
PMCPMC12219481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.