Evidence map›Paper›PMID 40601723›Full record

ArticleScience advances2025

The lipid bilayer strengthens the cooperative network of membrane proteins.

Shaima MuhammedNazaar, Jiaqi Yao, Matthew R Necelis, Yein C Park, Zhongtian Shen, Michael D Bridges, Ruiqiong Guo, Nicole Swope, May S Rhee, Miyeon Kim and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Molecular mechanisms of Kir channel gating.Biochemical Society transactions · 2026
    Review
  3. Review
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Shaima MuhammedNazaarDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-5507-1418
Jiaqi YaoDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
Matthew R NecelisDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0002-2448-982X
Yein C ParkThomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-5011-7421
Zhongtian ShenThomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-9619-6233
Michael D BridgesJules Stein Eye Institute, Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-9999-9106
Ruiqiong GuoDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
Nicole SwopeDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0001-9142-1828
May S RheeDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
Miyeon KimDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-9708-472X
Kelly H KimDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Wayne L HubbellJules Stein Eye Institute, Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Karen G FlemingThomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-5417-8830
Linda ColumbusDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0002-2574-0561
Seung-Gu KangSKKU Advanced Institute of Nano Technology (SAINT), Department of Nano Science & Technology, and Department of Nano Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea.ORCID 0000-0002-4010-0829
Heedeok HongDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-0118-5193

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID S WILLIAMS · 1985 to 2026
$16.8M
Program of Molecular BiophysicsT32GM135131 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Karen G. Fleming · 2020 to 2026
$5.4M
Biophysical understanding of pathogen-host membrane protein interactions for drug discovery and deliveryR35GM131829 · NIGMS · UNIVERSITY OF VIRGINIA · PI Linda M Columbus · 2019 to 2026
$3.2M
Mechanistic Understanding of Post-Translational Membrane Protein TargetingR35GM147522 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Hyojin (Kelly) Kim · 2022 to 2026
$1.9M
Forces Driving Membrane Protein FoldsR35GM148199 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Karen G. Fleming · 2023 to 2026
$1.9M
Folding and degradation of membrane proteinsR35GM144146 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Heedeok Hong · 2022 to 2026
$1.5M
MOLECULAR GENETICS OF EARLY EYE DEVELOPMENTZ01EY000311 · NEI · NATIONAL EYE INSTITUTE · PI TOMAREV, STANISLAV I · 1996 to 2008
$941k
Intramural NIH HHS Z01 EY000311NEI NIH HHS P30 EY000331NIGMS NIH HHS R35 GM131829NIGMS NIH HHS R35 GM144146NIGMS NIH HHS R35 GM147522NIGMS NIH HHS R35 GM148199NIGMS NIH HHS T32 GM135131
6 · The paper itself

Abstract

Membrane proteins fold and function in a lipid bilayer constituting cell membranes. Nonetheless, their structure and function can be recapitulated in diverse amphiphilic assemblies whose compositions deviate from native membranes. It remains unclear how various hydrophobic environments stabilize membrane proteins and whether lipids play any unique role in protein stability compared to other types of amphiphiles. Here, using the evolutionarily unrelated α-helical and β-barrel membrane proteins from

Indexed as

Escherichia coli ProteinsLipid BilayersMembrane ProteinsEscherichia coliHydrophobic and Hydrophilic InteractionsModels, MolecularProtein StabilityEscherichia coli ProteinsLipid BilayersMembrane Proteins

Identifiers

PMID40601723
PMCPMC12219509

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.