SynthesisPloS one2025
OCTA measurements in Behcet's disease across different stages of the disease activity: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Treat-to-target in Behçet syndrome.Nature reviews. Rheumatology · 2026Review
- Evaluation of structural and microvascular retinal and choroidal changes using optical coherence tomography angiography in rheumatoid arthritis.International ophthalmology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBehcet disease (BD) is an autoimmune disease characterized by diffuse all-sized obliterative vasculitis, thrombotic vasculopathy, and common ocular involvement. This study aims to evaluate the retinal microvascular alterations in BD using optical coherence tomography angiography (OCTA).
methodsPubMed, Embase, and Web of Sciences were systematically searched for relevant studies assessing OCTA measurements in BD and healthy controls (HCs). Meta-analysis was conducted on OCTA parameters with at least two studies using the same OCTA device, with similar case and control groups. A qualitative synthesis approach was used to report the data that could not be pooled.
resultsTwenty-eight related studies (769 BD subjects, 123 active BU eyes, 462 inactive BU eyes, 112 non-specified ocular BD, and 486 non-ocular BD eyes) were included. Patients with inactive Behcet uveitis (BU) and non-ocular BD showed a statistically significant greater FAZ size and lower superficial retinal capillary plexus and deep retinal capillary plexus vessel density (VD) in comparison to HCs, particularly in the parafoveal sector. Also, radial peripapillary capillary (RPC) VD was lower in patients with inactive BU than HCs. However, no significant difference in OCTA parameters was found in patients with active BU compared to HCs.
conclusionsMeta-analysis demonstrated reduced VD in various regions and greater FAZ size in superficial and deep retinal plexuses, particularly in inactive BU and non-ocular BD, which are mostly studied so far. However, more studies with larger sample sizes should draw a more definite conclusion. OCTA can provide valuable insights into retinal microvasculature changes in BD.
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