Evidence map›Paper›PMID 40601315›Full record

ArticleJAMA network open2025

Marginalized Neighborhoods and Health Outcomes in Younger Myocardial Infarction Survivors.

Leo E Akioyamen, Atul Sivaswamy, Olivia Haldenby, Husam Abdel-Qadir, Maneesh Sud, David A Alter, Clare L Atzema, Peter C Austin, Cynthia A Jackevicius, Moira K Kapral and 4 more

Abstract read
In one paragraph

Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Leo E AkioyamenDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Atul SivaswamyICES, Toronto, Ontario, Canada.
Olivia HaldenbyICES, Toronto, Ontario, Canada.
Husam Abdel-QadirDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Maneesh SudDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
David A AlterDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Clare L AtzemaDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Peter C AustinICES, Toronto, Ontario, Canada.
Cynthia A JackeviciusICES, Toronto, Ontario, Canada.
Moira K KapralDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Harlan M KrumholzCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.
Karen TuICES, Toronto, Ontario, Canada.
Harindra C WijeysunderaDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Dennis T KoDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Neighborhood characteristics may be independently associated with survival after acute myocardial infarction (AMI). Objective: To examine the association of living in a marginalized neighborhood with mortality and care for younger AMI survivors (aged <65 years) in a universal health care system. Design, Setting, and Participants: Population-based retrospective cohort using clinical and administrative databases in Ontario, Canada. Participants were younger patients hospitalized for their first AMI who received invasive evaluation and survived to 7 days after discharge between April 1, 2010, and March 1, 2019. Statistical analysis was performed between May 27, 2022, and March 31, 2025. Exposures: Neighborhood marginalization, a metric comprising material deprivation, residential instability, and dependency. Main Outcomes and Measures: All-cause death, all-cause hospitalizations, and subsequent AMIs. Proportional hazards regression models were used to quantify the association of marginalization with outcomes over 3 years. Results: Among 65 464 AMI patients (median age, 56 [IQR, 50-61] years; 22.9% female), increasing neighborhood marginalization was associated with higher rates of mortality beginning 30 days after discharge and persisting over time. At 3 years, mortality rates ranged from 2.2% in the least marginalized neighborhood quintile (Q1) to 5.2% in the most marginalized (Q5). Adjusted hazard ratios for mortality over 3 years of follow-up were significantly higher in patients from marginalized neighborhoods and ranged from 1.13 (95% CI, 0.95-1.35) in Q2 to 1.52 (95% CI, 1.29-1.80) in Q5. Over 1 year, differences were observed between Q1 and Q5 in visits to primary care physicians (Q1, 96.1%; Q5, 91.6%) and cardiologists (Q1, 88.0%; Q5, 75.7%), as well as diagnostic testing. Conclusions and Relevance: In this cohort study of younger AMI survivors with universal health care, living in marginalized neighborhoods was associated with adverse outcomes. The observed differences in health service utilization among marginalized patients warrant further investigation to better understand the underlying structural and systemic factors.

Indexed as

Myocardial InfarctionNeighborhood CharacteristicsResidence CharacteristicsSocial MarginalizationSurvivorsAdultFemaleHospitalizationHumansMaleMiddle AgedOntarioRetrospective Studies

Identifiers

PMID40601315
PMCPMC12223890

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.