Evidence map›Paper›PMID 40601229›Full record

ArticleCell biochemistry and biophysics2025

Design, Synthesis, and Evaluation of Benzoxazole-linked Pyrazole Hybrids as VEGFR-2-targeted Antiproliferative Agents.

Elif Deniz, Furkan Ozan Çöven, Ali Ergüç, Fuat Karakuş, Burak Kuzu

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elif DenizDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Türkiye.
Furkan Ozan ÇövenDepartment of Bioengineering, Faculty of Engineering and Natural Sciences, Manisa Celal Bayar University, Manisa, Türkiye.
Ali ErgüçDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Ondokuz Mayıs University, Samsun, Türkiye.
Fuat KarakuşDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Türkiye.
Burak KuzuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Türkiye. burakkuzu@yyu.edu.tr.

Funding

Yüzüncü Yil Üniversitesi BAP Project code: TYL-2024-11268
6 · The paper itself

Abstract

In this study, a series of benzoxazole-linked pyrazole compounds (20a-t) were synthesized and tested for their antiproliferative activity. Their effects on lung cancer (A549) and normal lung (CCD-34Lu) cell lines were evaluated using the MTT assay. Among them, compounds 20m and o showed strong antiproliferative effects, with IC

Indexed as

Antineoplastic AgentsBenzoxazolesDrug DesignPyrazolesVascular Endothelial Growth Factor Receptor-2A549 CellsCell Line, TumorCell ProliferationHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsBenzoxazolesKDR protein, humanpyrazolePyrazolesVascular Endothelial Growth Factor Receptor-2AntiproliferationBenzoxazoleMolecular dockingPyrazoleVEGFR-2

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.