ArticleAnnals of intensive care2025
Adherence to post-cardiac arrest care guidelines and impact on survival and neurological outcome.
Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Prognostic utility of the revised post-cardiac arrest syndrome for therapeutic hypothermia score in pediatric patients with post-cardiac arrest syndrome.Resuscitation plus · 2026Article
- The IHCA paradox: high early mortality, yet comparable long-term survival in STEMI patients.Internal and emergency medicine · 2026Article
- Psychological and cognitive support after cardiac arrest: a systematic review.Resuscitation plus · 2026Review
- Association between early post-resuscitation heart rate and survival with neurological recovery in a pig model of cardiac arrest.Resuscitation plus · 2026Article
- Association between early arterial pH, base excess and lactate and 24-h mortality and neurological outcomes after cardiac arrest and cardiopulmonary resuscitation: a translational study.Resuscitation plus · 2026Article
- Article
- Incidence and prognostic impact of delirium after cardiac arrest: a systematic review and meta-analysis.Resuscitation plus · 2026Review
- CardioPulmonary resuscitation withResuscitation plus · 2025Article
- Blood glucose upon return of spontaneous circulation and neurological outcomes following out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- Adherence assessment in post-cardiac arrest care: are physiological targets sufficient? : Author.Annals of intensive care · 2025Article
- Hitting the target or missing the point? A closer look at post-cardiac arrest guideline adherence.Annals of intensive care · 2025Article
- Tipping the balance: early post-resuscitation fluid accumulation and outcome after cardiac arrest.Critical care (London, England) · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundPost-cardiac arrest (CA) care guidelines (GLs) have been introduced in 2010 and periodically updated every 5 years since then (in 2015 and 2021). However, the impact of these GLs on patients' outcome remains underexplored. The aim of this study was to comprehensively evaluate and compare the impact of implementation of three consecutive post-CA GLs over 14 years, on patients' survival and neurological recovery.
methodsThis retrospective cohort study included adult patients resuscitated from CA and admitted to the intensive care unit (ICU) between 2011 and 2024. Patients were stratified into three cohorts based on the GL in use (GL2010, GL2015, and GL2024). Adherence to GL recommendations was assessed across seven macro-areas: coronary angiography, haemodynamic, ventilation, temperature control, general ICU management, multimodal neuroprognostication, and seizure control. Predictors of survival and favourable neurological outcome at ICU discharge were evaluated using multivariate logistic regression with LASSO selection. Outcome up to 6 months was also evaluated.
resultsA total of 275 patients were included over the 14-year period. Survival to ICU discharge increased from 39.5% in cohort 1 to 53.9% in cohort 3, together with favourable neurological outcome that improved from 30.9 to 42.7%. Adherence to GL recommendations significantly improved across most domains, particularly in haemodynamic management (from 32.0% in cohort 1 to 77.3% in cohort 3), temperature control (from 60.6 to 94.4%), and general ICU management (from 56.3 to 77.6%). Among all interventions, adherence to haemodynamic recommendations was independently associated with improved survival (OR = 2.20, 95% CI: 1.01-4.86).
conclusionsFollowing the implementation of updated post-CA care GLs, adherence to recommendations improved, particularly in haemodynamic management. Although no statistically significant improvements in survival or neurological outcomes were observed, these findings highlight the potential value of sustained GL-based care.
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